Sentences with phrase «isoforms differ»

While the two actin isoforms differ by only four amino acids, their mRNA coding sequences differ by almost 13 percent because of «silent» nucleotide differences that nevertheless encode the same amino acids.

Not exact matches

More than half of mammalian genes generate multiple messenger RNA isoforms that differ in their 3 ′ untranslated regions (3 ′ UTRs) and therefore in regulatory sequences, often associated with cell proliferation and cancer; however, the mechanisms coordinating alternative 3 ′ - UTR processing for specific mRNA populations remain poorly defined.

A few receptor genes have more than 8 different isoforms (38 VRs and 10 ORs), however in most of these cases this is due to the presence of several transcription start sites (TSS) or exons that differ in length by just a few nucleotides, so several of the final transcripts differ only very slightly (Figure S7B).

Although the unc - 7 locus encodes three isoforms that differ in their amino termini, two of these appear functionally equivalent, and the ability of UNC - 7L to contribute to junctions is still uncertain.