Sentences with phrase «isoforms of»

Of the three isoforms of ApoE, E4 is unique in its inability to bind tau.

11β - Hydroxysteriod dehydrogenase I and II (isoforms of enzyme that converts cortisol to cortisone) activity shown by:

ΔNp63 and all isoforms of p73 were not detected in either central or peripheral corneal endothelium.

However, transcripts for ΔNp63 and all isoforms of p73 were not detected in peripheral or central corneal endothelial cells (Figure 1, Figure 2).

The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in stratified squamous epithelium [21,34].

Both mRNA detection and protein detection was negative for all isoforms of p73.

Using the yeast two - hybrid screen, we have isolated two clones that specifically interact with the three isoforms of Rab6 present in mammalian cells (Rab6A, A» and B).

The isoforms of this histone play complex regulatory roles in several cellular processes — epigenetic regulation of gene expression, selective regulation of developmental genes, and telomere maintenance — that could contributed to tumor growth and progression if dysregulated.

At least six isoforms of actins are known in mammals and other vertebrates: alpha (ACTC1, cardiac muscle 1), alpha 1 (ACTA1, skeletal muscle) and 2 (ACTA2, aortic smooth muscle), beta (ACTB), gamma 1 (ACTG1) and 2 (ACTG2, enteric smooth muscle).

Two isoforms of the cold - inducible mRNA - binding protein RBM3 localize to dendrites and promote translation.

(C) Gel image of RT - PCR results showing multiple transcript isoforms of Bsl1 in bsl1 - 2 inflorescence primordia at 15 DAS compared with A10.1.

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL - 6 corepressor.

This activity is typical of both intracellular and cellular plasma membrane isoforms of this enzyme [28].

Identification and expression of novel isoforms of human stromal cell - derived factor 1.

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1?a and HSF1?ß, Regulate Chaperone Protein Gene Transcription.

All these functions will have to be investigated in the isoforms of W01A8.1 in the future.

Mice that lack either IL - 15 or IL - 15Rα have unique phenotypes (14, 15, 27, 28), and multiple isoforms of IL - 15Rα exist that can either potentiate or inhibit the effects of IL - 15 (29 — 33).

In the current study, deploying TFPI and an isoform of tenascin C, TNC - FN IIIC, with CA 19 - 9 improved performance discriminating stage I and II disease from healthy or benign disease controls.

An isoform of amphiphysin 2 concentrated at T - tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells.

Oocytes contain a high concentration of an oocyte - specific isoform of p63 which plays a key role as a quality control factor in causing infertility.

Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF - A.

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

The study published in Molecular Cell is entitled, «The Short Isoform of BRD4 Promotes HIV - 1 Latency by Engaging Repressive SWI / SNF Chromatin Remodeling Complexes.»

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast.

The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR - mediated ras signaling.

The purpose of these studies was to learn whether one isoform of nonmuscle myosin II, specifically nonmuscle myosin II - A, could functionally replace a second one, nonmuscle myosin II - B, in mice.

However, in this investigation no isoform of p73 was found in endothelial tissues.

Not exact matches

These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.

Carstens hopes that further study of Esrp1 and Esrp2, and in particular the proteins whose splice isoforms they control, will uncover useful clues about how these defects arise and how they might be remedied.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

We are one of the most referenced companies in the industry and continue to collaborate to develop products such as isoform - specific AKT antibodies, green fluorescent protein (GFP) and red fluorescent protein (RFP) antibodies, and fluorochrome - conjugated secondary antibodies.

Its two isoforms — MAO - A and MAO - B — work together to help maintain the balance of neurotransmitters in the brain.

The roadmap outlines future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, the coordination of regenerative and ablative technologies, and methods of slowing metabolic activity while preserving cognitive function.

Called isoforms, these proteins are produced when only part of the gene's code is read.

«Our results support that gene expression responses of PGC - 1α isoforms may have an important role in exercise - induced muscle adaptations,» the researchers stated.

The isoforms beta ARK - 2 and beta - arrestin - 2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur.

In the context of the current study, TRAF6's regulation of RNA isoform expression is important to the function of hematopoietic cells and reveals another dimension to how cells respond to infection, Starczynkowski said.

The reason it's called MGF — mechano growth factor — is that the mRNA [messenger RNA] of isoform 4 is elevated when mechanical stress is applied to muscle tissue.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

While the two actin isoforms differ by only four amino acids, their mRNA coding sequences differ by almost 13 percent because of «silent» nucleotide differences that nevertheless encode the same amino acids.

At SAGE KE (http://www.sciencemag.org/sciext/drugdisc/#insageke), Raber describes the role of isoform - dependent interactions of apoE with androgens and androgen receptors in the progression of Alzheimer's disease.

These changes in mitochondria - and calcium - related markers occurred without any changes in the myosin heavy chain isoform composition of these muscles, as assessed by quantitative PCR (qPCR)(data not shown).

The muscles from IL - 15Rα — KO mice had a greater relative expression of the SERCAII isoform and lower mRNA and protein levels of calsequestrin, both characteristic of slow muscles (52).

Adding to the documented complexity of IL - 15 — related activity, multiple isoforms and splice variants of IL - 15Rα exist as both membrane - bound and soluble forms that can either inhibit or potentiate IL - 15 biological activity (29 — 33).

Although the current study demonstrates that loss of IL - 15Rα promotes this phenotype, future studies are needed to determine the roles of specific IL - 15Rα isoforms in muscle, as well as the associations of additional IL15RA polymorphisms in muscle phenotypes in humans.

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes.

(Mixture - of - Isoforms) for isoform quantitation using RNA - Seq is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA - Seq data, and identifies differentially regulated isoforms or exons across Isoforms) for isoform quantitation using RNA - Seq is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA - Seq data, and identifies differentially regulated isoforms or exons across isoforms or exons across samples.

Since using the WormBase name of W01A8.1 (MDT - 28) would be misleading, the gene is referred here by the cosmid name W01A8.1, which gives rise to at least three protein isoforms designated W01A8.1 a, W01A8.1 b, and W01A8.1 c from at least seven different transcripts (W01A8.1 a. 1, W01A8.1 a. 2, W01A8.1 b. 1, W01A8.1 b. 2, W01A8.1 b. 3, W01A8.1 c. 1, W01A8.1 c. 2).