Sentences with phrase «isoforms which»

Regarding other members of the p53 family, the p63 gene encodes 6 isoforms which migrate on gels in sizes from 32 - 90 kDa [21,30].

Not exact matches

These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.

Oocytes contain a high concentration of an oocyte - specific isoform of p63 which plays a key role as a quality control factor in causing infertility.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

To test this, we created translational reporter transgenes regulated by the putative endogenous promoter expressing isoform b and lines in which the genomic locus was tagged by an in - frame C - terminal GFP cassette.

Since using the WormBase name of W01A8.1 (MDT - 28) would be misleading, the gene is referred here by the cosmid name W01A8.1, which gives rise to at least three protein isoforms designated W01A8.1 a, W01A8.1 b, and W01A8.1 c from at least seven different transcripts (W01A8.1 a. 1, W01A8.1 a. 2, W01A8.1 b. 1, W01A8.1 b. 2, W01A8.1 b. 3, W01A8.1 c. 1, W01A8.1 c. 2).

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

The demand for splicing is high in retinal cells, which have lots of tissue - specific isoforms.

Here we use a chemical genetics approach using knock - in mice in which either p38alpha or p38beta kinase has been rendered resistant to the effects of specific inhibitors along with p38beta knock - out mice to dissect the biological function of these specific kinase isoforms.

Because the polyT repeat is reported as the key variant to define TOMM40 clades A and B, 12 we used this marker and APOE isoform information to perform analyses based on phylogenetic groups as described by Roses et al. 12 Haplotype phase was estimated using PHASE software.22 The phylogeny, which represents the evolutionary relatedness of the haploytpes, was estimated using neighbor - joining with 10 000 bootstrapping replicates in the CLC DNA workbench (CLC bio, Aarhus, Denmark)(Supplemental Figure 3; http://neuroscienceresearch.wustl.edu/Pages/cruchaga2011.aspx).

rs7412 and rs429358 (which define the APOE ε2, ε3, and ε4 isoforms), rs1160985, and rs4420638 (TOMM40) were genotyped using KASPar (KBioscience, Herts, United Kingdom) and TaqMan (Applied Biosystems, Foster City, California) genotyping technologies.

We replaced exon 3, which encodes a part of the RNA binding domain and is present in all Boule isoforms (Figure 3C), with a lacZ - neo vector through homologous recombination in embryonic stem cells.

There are a total of 12 possible isoforms, which are distributed in the human body in a tissue - specific manner.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

The p63 bands migrated to 60 kDa, which is consistent with the TAp63 isoform.

Cortisone is produced by the action of 11β - hydroxysteroid dehydrogenase (11β - HSD), an enzyme with two isoforms, the first of which, 11β - hydroxysteroid dehydrogenase I (11β - HSD I) catalyzes cortisone into cortisol, enabling rapid supply of the active hormone as needed.