Sentences with word «isogenic»

Pairwise tests among six isogenic lines ofDrosophila melanogaster were performed to determine whether there is a genotype - specific interaction in the success of sperm.

This study defines a network of synthetic sick / lethal interactions with a set of query genes in a series of isogenic cancer cell lines.

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

The team used clustered regularly - interspaced short palindromic repeats (CRISPR) / Cas9 to edit the mutations into isogenic human pluripotent stem cells.

The 1st and 3rd chromosome of the D. melanogaster stock with wAu were replaced with DrosDel w1118 isogenic chromosomes using a first and third double balancer line.

They verified that these epilines were indeed isogenic, or genetically identical, by sequencing the genome of each.

Bacterial populations pose an intriguing puzzle: in so - called isogenic populations, all bacteria have the same genes, but they still behave differently, for example grow at different speeds.

As these strains are ∼ 81 % congenic, but not isogenic, they exhibit different phenotypes under various conditions, and their progeny (88 were examined) showed a range of phenotypes (Figure S11).

An intact genome, isogenic hiPSC model from an individual with mosaic Down syndrome reveals neurogenesis and mitochondrial defects caused by Trisomy 21

Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting.

His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.

In order to directly compare these two strains in Drosophila melanogaster, we used Wolbachia - infected lines in a genetically identical DrosDel w1118 isogenic background [39].

Near - isogenic lines for measuring phenotypic effects of DIMBOA - Glc methyltransferase activity in maize

To create cell models for the discovery of disease etiology, progression, and treatment, isogenic cell lines can be created from healthy or sick individuals, then compared (Figure 1).

All these cells were isogenic, which means they all had the same gene set.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

Publishing in Scientific Reports researchers claim NK603 genetically modified maize and its isogenic control are not «substantially equivalent».

Publishing in Scientific Reports researchers report NK603 genetically modified maize and its isogenic control are not substantially equivalent.

Since the three colonies are isogenic, differences between them could explain the observed morphological discrepancies.

For example, a transcription factor equally prevalent in two isogenic cells might be bound to a promoter in one and unbound in another, subject to the dictates of statistical mechanics.

There are a large number of laboratory strains available, and their long breeding history means that mice of a single laboratory strain are isogenic.

We have isogenic lines and hiPSCs with tagged endogenous proteins in hand.

Demonstrated that laboratory - adapted CCR5 - tropic 81A virions fuse rapidly and efficiently to immature MDDCs, whereas NL4 - 3, the isogenic CXCR4 - tropic counterpart of 81A, fuse slowly and inefficiently to both immature and mature MDDCs.

This study defined about 200 negative genetic interactions in the isogenic cancer cell line background.