Sentences with phrase «isogenic cell»

These isogenic cell lines can be used not only to understand the cellular consequences of disease mutations, but also to perform high throughput genetic and pharmacological screens to both understand the underlying pathological mechanisms and to develop novel therapeutic agents to prevent or treat such diseases.

To create cell models for the discovery of disease etiology, progression, and treatment, isogenic cell lines can be created from healthy or sick individuals, then compared (Figure 1).

For example, a transcription factor equally prevalent in two isogenic cells might be bound to a promoter in one and unbound in another, subject to the dictates of statistical mechanics.

Not exact matches

All these cells were isogenic, which means they all had the same gene set.

His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.

Also, pESC lines, that carry isogenic genome information from the oocyte donors, can be derived and may represent a potential alternative source of stem cells for basic scientific studies as well as novel therapeutic application.

Epigenetic modifications in bacteria, such as DNA methylation, have been shown to affect gene regulation, thereby generating cells that are isogenic but with distinctly different phenotypes.

This study defines a network of synthetic sick / lethal interactions with a set of query genes in a series of isogenic cancer cell lines.

This study defined about 200 negative genetic interactions in the isogenic cancer cell line background.