In the new study, a team led by Wiktorowicz ground up a small portion
of each
of the pottery
fragments (or sherds), used detergent and other chemicals to dislodge any
proteins stuck to them, and
isolated and analyzed the
protein fragments using various techniques.
(A)
Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence
of different concentrations
of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic
proteins, including the Alzheimer's disease — associated
protein Tau (the K18
fragment) and the bacterial amyloid Mcc.