Mycobacterium tuberculosis (Mtb) DprE1, an essential
isomerase for the biosynthesis of the mycobacterial cell wall, is a validated target for tuberculosis (TB) drug development.
Not exact matches
Dr Matthew Gregory, a corresponding author of the paper and CEO of
Isomerase Therapeutics Ltd, said: «The work described in this paper has important ramifications
for the natural products field and synthetic biology generally.»
Endothelium - derived but not platelet - derived protein disulfide
isomerase is required
for thrombus formation in vivo.
Histopathology and Functional Correlations in a Patient with a Mutation in RPE65, the Gene
for Retinol
Isomerase.
A critical role
for extracellular protein disulfide
isomerase during thrombus formation in mice.
The disulfide
isomerase ERp57 is required
for fibrin deposition in vivo.
Stephen Hughes, Ph.D., research molecular biologist at the USDA - ARS, described an automated process
for high - throughput transformation (with bacterial xylose
isomerase and xylose kinase genes), mutagenesis, and screening of yeast to select
for fast - growing strains optimized
for anaerobic growth on xylose.