Not exact matches
According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight
junction proteins, which regulate transport into and
between cells.
Through further testing, they figured out that when Notch1 is activated and its intracellular domain is released, its TMD assembles a complex in the membrane with the
proteins VE - cadherin, Rac1, LAR, and Trio, which collectively assemble and maintain the adherens
junctions between cells and distribute actin fibers against the cell membrane to support those
junctions.
By interacting with the actin cytoskeleton, underneath the cell outer membrane, and other structural
proteins of the tight
junctions, Alix ensures the formation of the actomyosin - tight
junction complex at a specific position
between adjacent cells.
In what reviewers described as a «technological tour de force,» John R. Cirrito and David M. Holtzman of the Washington University School of Medicine in St. Louis traced production of a destructive Alzheimer's
protein, known as amyloid - beta (right), to the
junctions between neurons called synapses.
The
protein encoded by Shank3 is found in synapses — the
junctions between neurons that allow them to communicate with each other.
Correct tight
junctions between cells labeled in yellow due to the presence of the
protein PARD3.
Using colorfully labeled antibodies to light up the new
protein under their microscopes, they found that it was present where Listeria entered cells and also present at adherens
junctions between epithelial cells.
In fact, it metabolizes into prostaglandin E2 (PGE2)-- a small signaling
protein that helps regulate
junctions between cells.
Increased intestinal permeability When the intestinal lining is damaged, the tight
junctions between the intestinal wall and the bloodstream can no longer prevent incompletely digested
proteins, bacteria or bacterial fragments from leaking out into the bloodstream.
In the small intestine, gluten triggers the release of zonulin, a
protein that regulates the tight
junctions between epithelial cells and therefore intestinal, but also blood - brain barrier function.
Probiotics may help to prevent this by closing the «tight
junctions,» the spaces
between cells in the small intestines so that these
proteins can't escape and cause the immune system to overreact.