Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase - induced alterations of tight
junction protein expression.
Enterohemorrhagic E. coli alters murine intestinal epithelial tight
junction protein expression and barrier function in a Shiga toxin independent manner.
Not exact matches
«Specifically, the
protein expression responsible for endothelial cell degeneration and tight
junction damage we identified in this study needs to be confirmed through further tests.
However, the team was able to show that so - called tight
junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of
expression in the absence of bacteria.
Our work provides evidence that Cd14 is pivotal for regulating tight
junction proteins by reducing the
expression of pro-inflammatory cytokine.
These increases were accompanied by disruption of tight
junctions and a decrease in
expression of the tight
junction protein occludin.
Exposure of germ - free adult mice to a pathogen - free gut microbiota decreased BBB permeability and up - regulated the
expression of tight
junction proteins.