In the latter group, a neutralizing antibody blocked TNF and prevented it from binding to a receptor on the premalignant liver cells; loss of the receptor prevented the TNF from triggering a molecular cascade that turns on the NF -
kB master switch.
Not exact matches
For example, nuclear factor - kappa B (NF -
kB) is a complex of proteins that acts as a
master switch for turning inflammation genes on and for controlling cell death.
A molecule called NF -
kB acts as the
master switch for inflammation, activating over 400 pro-inflammatory genes in the body.