Figure 2 (middle line) shows that 50 nmol
kahweol induced apoptosis in a small percentage of cells but this effect did not seem to be endothelial cell specific, since only few apoptotic nuclei corresponded to endothelial cells.
Data obtained on the effects of kahweol on endothelial cell invasion (as determined by a continuous fluorescent assay) clearly show that
kahweol induces an anti-invasive effect in HUVEC in a dose - dependent manner (Figure 7).
Not exact matches
Figure 8 (C) shows that
kahweol - treatment
induces a dose - dependent decrease in the levels of urokinase in HUVEC conditioned media, with an almost complete inhibition at 50 µM
kahweol.
Although 50 nmol of
kahweol per CAM was required to observe in vivo inhibition of angiogenesis in 100 % of treated eggs, as little as 10 nmol of
kahweol was enough to
induce clear inhibition of angiogenesis in 25 % of the tested eggs in the CAM assay.