Sentences with phrase «kahweol inhibits»
Figure 9 (A and B) shows that kahweol inhibits in a dose dependent manner the expression of COX - 2 protein by HUVEC.
http://journals.plos.org/
Our results indicate that kahweol inhibits two key inflammatory mediators, COX - 2 and MCP - 1, which are also related with angiogenesis.
Not exact matches
In the CAM assay, the inhibitory doses exhibited by kahweol are similar to those of other anti-angiogenic compounds found by us to inhibit angiogenesis in the CAM assay [10], [19], and much lower than those of other anti-angiogenic compounds [21].
On the other hand, the present research work shows a confirmatory evidence of the potential of kahweol to inhibit in vivo angiogenesis, by using another completely independent model system, namely, that of genetically modified zebrafish.
The kahweol concentrations required to inhibit the differentiation of HUVEC cells did not affect their viability (results not shown).
A third line of evidence showing the potential of kahweol to inhibit overall angiogenesis is provided by the ex vivo model of the mouse aortic ring assay.
Our results in the zymographic assays for gelatinase and urokinase activities clearly showed that, in fact, kahweol was able to inhibit the expression of both MMP - 2 and uPA, identifying them as two relevant molecular targets for kahweol.