By
keeping telomeres long, ATRX mutations give cells the ability to endlessly divide, a hallmark of cancer.
Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for
keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.
Blackburn conducted research focused on mothers caring for children with autism and other chronic conditions, and found that moms who were more resilient to stress — perceiving their situation as a challenge, rather than something hopeless or overwhelming —
kept their telomeres longer.
Here are a few things Blackburn suggests anyone can do to
keep their telomeres long.
Doing so
keeps the telomeres found on the ends of your DNA strands long and able to protect chromosomes from deterioration.
However, stem cells and some cancer cells make enough telomerase to
keep their telomeres from shortening, effectively stopping the aging clock and allowing a seemingly unlimited number of cell divisions.
Telomerase, the enzyme that tends your telomeres, helps to
keep your telomeres long as you age.
Not exact matches
Death is explained by other scientific processes, such as protein decay,
telomere shortening, lack of nutrients to
keep the body going, and many other things.
Blackburn and Szostak determined that it was a specific DNA sequence in the
telomeres that
kept chromosomes from fraying whenever they were copied when a cell splits in two.
The boosted genes had three main beneficial effects: improving the efficiency of mitochondria, the powerhouse of cells; boosting insulin production, which improves control of blood sugar; and preventing the depletion of
telomeres, caps on chromosomes that help to
keep DNA stable and so prevent cells wearing out and ageing.
If our
telomeres have grown dangerously short, can we do anything to
keep them from shortening further?
He suspects that the telomerase levels are sufficient to lengthen the shortest
telomeres, but not
keep them all long and healthy.
Telomeres are the caps at the end of chromosomes that
keep them from shrinking when cells replicate.
You've said, «
Telomeres just grabbed me and
kept leading me on.»
But cancer cells
keep on going by deploying one of two strategies to reconstruct
telomeres.
One way to
keep stem cells and other cells working is to avoid the loss of
telomeres capping the ends of chromosomes.
«Our hope is that by understanding this relationship, we may be able to predict which people are most likely to develop certain cancers so they can take preventive measures and perhaps be screened more often, as well as develop therapies to help our DNA
keep or return its
telomeres to a healthy length.»
The limitation may be that normal cells do not produce active telomerase, which can rebuild the
telomeres and
keep cells from becoming senescent.
Much like the plastic caps on our shoelaces that
keep them from fraying,
telomeres protect our chromosomes and preserve our genetic information.
Telomeres work to
keep chromosome ends from deteriorating or fusing with a neighboring chromosome, affecting how quickly cells age and die.
During the DNA replication process,
telomeres keep the DNA together (like how the plastic caps on the end of shoelaces
keep them from unraveling).
While the consumption of whole plant foods has been associated with longer protective
telomeres, the tips on each of our chromosomes that
keep our DNA from unraveling and fraying, in contrast, consuming refined grains, soda, dairy, and meat, including fish, has been linked to shortened
telomeres, a sign of cellular aging.
Scientists were examining data which
kept records of
telomere length.
Telomeres keep your cells young and
keep them from losing genetic information when your cells divide.
Telomeres are often compared to the caps on the ends of shoelaces that
keep them from fraying.
Consuming fruits and veggies, and not smoking, has also been associated with longer protective
telomeres, the caps on the tips of our chromosomes that
keep DNA from unraveling.