Sentences with word «keratinocyte»

Residual transgenes present after piggyBac - mediated human iPSC production affect the functionality of keratinocytes derived from such iPSCs compared to iPSCs completely free of transgene sequences

Right: Immunofluorescence analysis of keratin 14 and TRP1 in keratinocytes after 3 days of coculture with melanocytes derived from pluripotent stem cells.

TL1A is released by skin cells known as keratinocytes, and activates not only Tregs but also ILC2 and TH2 effector cells.

... Traditionally, broadband UVB phototherapy has been used to treat psoriasis, which is an inflammatory skin disease, characterized by keratinocyte hyperproliferation with 1 - 2 percent prevalence in the general population.

This suggestion is also consistent with primary keratinocyte holoclones containing normal stem cells (2 — 4).

«We suspect that these skin - resident T cells also help protect keratinocytes from ultraviolet - induced DNA damage,» MacLeod said.

Home - Salk News - Salk researchers successfully reprogram keratinocytes attached to a single hair

Speaker: Dr. Dorothy Supp Title: The role of epidermal keratinocytes in keloid scarring.

[10] Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function.

But mounting evidence implicates the immune system in the overproduction of cell - signalling molecules called cytokines, which stimulate skin cells called keratinocytes to express genes that maintain an inflammatory microenvironment.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

There are clinical trials, which have shown that both omega 5 and omega 7 fatty acids stimulate keratinocyte proliferation, which is known to promote regenerations of the epidermis.

For the first set of experiments, first author Trond Aasen, Ph.D., a postdoctoral researcher at the Center of Regenerative Medicine in Barcelona, used viral vectors to slip the genes for the master regulators Oct4, Sox2, as well as Klf4 and c - Myc into keratinocytes cultured from human skin explants.

Like keratinocyte holoclones, cancer cell holoclones have been hypothesized to contain self - renewing stem - like cells although direct evidence supporting this hypothesis is still lacking.

The researchers obtained a small biopsy from a nonblistering skin section, which was used to grow keratinocyte cultures in the laboratory.

Like keratinocyte clones (2 — 4), prostate cancer cell holoclones consisted of tightly packed, small cells and paraclones of larger and fewer cells, whereas the meroclones were made of cells of intermediate sizes and numbers (Supplementary Fig.

Left: Immunofluorescence analysis of keratin 14 in keratinocytes derived from pluripotent stem cells.

Vitamin D has been shown to be active in the nuclei of the epidermis tissue where it enhances keratinocyte differentiation.

Just why keratinocytes appear to be much more malleable than other cell types is still an open question.

Ratite oils promote keratinocyte cell growth and inhibit leukocyte activation.

Researchers uncover the complex mechanisms acting between keratinocytes and mesenchymal stem cells which could be exploited to accelerate wound healing and improve wound closure.

Comparative analysis of canine dermatophytosis and superficial pemphigus for the prevalence of dermatophytes and acantholytic keratinocytes: a histopathologic and clinical retrospective study.

Reduces Scarring - Pomegranate oil stimulates keratinocytes, cells in the outer layer of skin, this process can help to reverse skin damage.

They cultured a single layer of normal keratinocytes with a mixture of six different cytokines known to be involved in psoriasis, and found that it induced the expression of psoriasis - related genes.

Between 2009 and 2013, the Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial randomly assigned 932 veterans who each had at least two prior basal cell carcinomas (BCCs) or SCCs to either receive the 5 - FU cream or a cream just like it but without the active ingredient as an experimental control.

Cell proliferation increased by 32 per cent and cell migration by nearly half when keratinocytes in a test tube and in culture were mixed for five days with Sandalore.

Primary keratinocytes exhibit three typical clonal morphologies represented by holoclones, meroclones, and paraclones, with holoclones containing self - renewing stem cells, and meroclones and paraclones containing more mature and differentiated cells.

For the expansion and differentiation of human keratinocyte stem cells for permanent skin restoration in victims of extensive burns.

In fact, they repeatedly generated iPS cells from the tiny number of keratinocytes attached to a single hair plucked from a human scalp.

«We checked a whole rainbow of cells and found keratinocytes to be the easiest to be reprogrammed,» says Belmonte.

These cells are found between the basal keratinocytes (this is the major constituent of epidermis.

Antibiotic - induced inflammatory markers in canine keratinocytes as potential factors in the pathogenesis of skin drug hypersensitivity.

This requires the activation of progenitor keratinocyte (PK) cells that turn into new follicles.

The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer

Green tea for example includes a class of polyphenol compounds called catechins that enhance natural would healing and at certain concentrations, have the ability to stimulate aged keratinocytes and reduce healing time.

The surgery is known as melanocyte - keratinocyte transplantation or MKTP.

In humans, iRhoms have been implicated in EGFR - mediated keratinocyte proliferation and cancer growth, but the molecular mechanisms underlying these biological functions have not been well defined.»

The new findings suggest that Neanderthal genetic variants increase the risk of developing sun - triggered skin lesions known as keratoses, which are caused by abnormal keratinocytes.

Even before those other immune cells arrived on the scene and inflammation set in, the IL - 17A induced local keratinocytes to start making special proteins that are known to combat bacteria, viruses and other microbes — and are also known to promote the crucial skin regrowth and remodeling that are needed to heal a wound.

«This «cross-talk» between skin - resident T cells and nearby keratinocytes is critical for re-establishing the skin barrier following wounding,» MacLeod said.

In psoriasis, T lymphocytes also drive an alteration in healthy keratinocytes, accelerating their life cycle.

UT Southwestern is the only center in the United States to use this technique and one of only two to perform this type of cell transplant surgery, called non-cultured epidermal suspension (NCES) grafting, cellular grafting or melanocyte keratinocyte transplant procedure (MKTP).

As a result, new keratinocytes move to the outer layer of skin faster than old skin cells can be sloughed off.

The top four images, from left to right, show Keratinocyte - derived neural crest stem cells turning into neurons as shown by typical neuronal morphology.

For keratinocytes derivation, pluripotent stem cells were seeded onto a feeder layer in a medium supplemented by a high concentration of BMP4 during 40 days.