Sentences with phrase «keratinocytes from»

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AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS - Induced Proinflammatory Response in Human Keratinocytes.

A comparison of epidermal equivalents generated from iPSC, hESC and primary human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.

These keratinocytes were then used to manufacture 3D epidermal equivalents in a high - to - low humidity environment to build a functional permeability barrier, which is essential in protecting the body from losing moisture, and preventing the entry of chemicals, toxins and microbes.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

For example, earlier research suggested that Neanderthal DNA influenced skin cells known as keratinocytes that help protect the skin from environmental damage such as ultraviolet radiation and germs.

It is believed to result from a combination of genetics and environmental factors such as irritants and allergens that drive T lymphocytes to produce factors that cause abnormal changes in keratinocytes, the predominant cell type in the outermost layer of skin, as well as changes in other cells in the underlying dermis.

In general, founder cells are easy to acquire from a donor and come in one of four types: fibroblasts, keratinocytes, peripheral and umbilical cord blood, and dental pulp cells.

The top four images, from left to right, show Keratinocyte - derived neural crest stem cells turning into neurons as shown by typical neuronal morphology.

Left: Immunofluorescence analysis of keratin 14 in keratinocytes derived from pluripotent stem cells.

After this period of induction, keratinocytes derived from pluripotent stem cells were isolated and amplified to obtain a homogenous and pure population of keratinocytes presenting all the phenotypic characteristic of adult keratinocytes.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

Gianneschi and his team found that the synthetic melanin nanoparticles in their experiments were not only absorbed and distributed normally by the keratinocytes in the epidermis, but they also protected human skin cells from UV radiation damage.

Unlimited source of keratinocytes and melanocytes derived from pluripotent stem cell for epidermis cell therapy

In parallel, the generation of functional melanocytes from pluripotent stem cells, capable of producing melanosomes and transferring them to keratinocytes, will facilitate in vitro analysis of molecular mechanisms underlying melanocytic defects observed in genetic diseases such as neurofibromatosis or albinism.

Homogenous and functional population of keratinocytes and melanocytes derived from pluripotent stem cells were generated by designing a multi-step sequential protocol respecting the chronobiology of epidermis formation during human ontogenesis.

Residual transgenes present after piggyBac - mediated human iPSC production affect the functionality of keratinocytes derived from such iPSCs compared to iPSCs completely free of transgene sequences

In fact, they repeatedly generated iPS cells from the tiny number of keratinocytes attached to a single hair plucked from a human scalp.

This differentiation is triggered by the endogenous Notch inhibitor Numb, which is upregulated in the stem cells by Wnt7a derived from UV - irradiated keratinocytes.

«We plucked a single hair from a co-worker's scalp and cultured the keratinocytes, which are found in the outer root sheet area,» recalls Aasen.

The researchers then successfully prodded what they call keratinocyte - derived iPS cells or KiPS cells to distinguish them from fibroblast - derived iPS cells into becoming all the cell types in the human body, including heart muscle cells and dopamine - producing neurons, which are affected by Parkinson's disease.

For the first set of experiments, first author Trond Aasen, Ph.D., a postdoctoral researcher at the Center of Regenerative Medicine in Barcelona, used viral vectors to slip the genes for the master regulators Oct4, Sox2, as well as Klf4 and c - Myc into keratinocytes cultured from human skin explants.

The research, described in the journal Stem Cells under the title «Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes of Health.

Melanin produced by melanocytes, is stored within melanosomes and is transferred to keratinocytes by a process known as cytocrinia (the same process by which melanin is transferred, in a normal epidermis, from melanocytes to keratocytes).

These malanosomes gather within the cytoplasm of keratinocytes and protect the skin from the harmful effects of ultraviolet radiation.