Gould and Georgiou say that their results don't necessarily invalidate previous studies; they simply show that
ketamine experiments in their lab work only when men inject the mice.
The head of Georgiou's lab, neuroscientist Todd Gould, learned that antidepressant researcher Ronald Duman at Yale University in New Haven, Connecticut, was seeing similar effects with female researchers in his lab that were working on
ketamine experiments.
Not exact matches
In a series of
experiments using mouse and rat models of depression reported today in Nature, Hu and her colleagues found that
ketamine did affect the lateral habenula — but it was the pattern of firing, rather than the overall amount of activity, that proved crucial.
Mouse
experiments with the popular club drug
ketamine may be skewed by the sex of the researcher performing them, a study suggests.
Adult female Sprague Dawley rats (3 months old, Harlan) were used in all in vivo spinal cord injury
experiments and were anesthetized by injection of a cocktail containing
ketamine and xylazine.
This important conclusion, albeit from tightly logical
experiments in mice, must remain tentative until HNK is shown to be effective in patients with depression without the dissociative effects of
ketamine.