Further experimentation found that during fasting, a microbiota - dependent increase in hepatic
ketogenesis occurs, regulated by PPAR - ɑ signaling.
Therefore, when insulin levels are high, fatty acids are not well used as fuel and no significant
ketogenesis occurs.
Not exact matches
Pathological ketosis
occurs due to uncontrolled rates of
ketogenesis (10 - 15mmol).
This condition seen in prolonged fasting, type 1 diabetes and high - fat / low - carbohydrate diets leads to the production of higher - than - normal levels of so - called ketone bodies (KBs), that is, acetoacetate, β - hydroxybutyric acid and acetone — a process called
ketogenesis and which
occurs principally in the mitochondrial matrix in the liver.6