"Ketone metabolism" refers to the process through which the body breaks down fat into energy molecules called ketones. This occurs when the body lacks enough carbohydrates to produce energy, forcing it to rely on stored fats.
Full definition
They found that levels of an enzyme involved
in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.
Because cancer cells in general are metabolically inflexible, we are able to take advantage
of ketone metabolism as a way of placing cancer cells in a weakened state.
There is data to show that some tumor types actually can survive and thrive
on ketone metabolism (1, 2, 3).
The traditional or modified ketogenic diets should not be used in individuals who have fatty acid oxidation defects, pyruvate carboxylase deficiency, primary carnitine deficiencies, organic acidurias, defects
in ketone metabolism, disorders that require high dietary carbohydrates as part of their treatment, severe liver disease or hypoglycaemia under investigation (4).
I consider this situation however to be extremely unlikely (and undesirable) because at low levels of exercise fat and / or
ketone metabolism would be very active aerobically and at high levels then lactate would become the primary fuel source for the aerobic system.
It may also help alleviate the fatigue and lethargy some experience while making the transition from a glucose to
a ketone metabolism.
Brain metabolism different than the metabolism of other organs and it appears that
ketone metabolism in the brain conveys a therapeutic benefit in many neurological conditions.
Ketosis is a metabolic state that occurs when dietary carbohydrates are in such low quantities that your body must rely almost exclusively on fatty acid oxidation and
ketone metabolism to produce ATP.
«The smelly factor comes from the fact that acetone, a byproduct of
ketone metabolism, seeps out of your body,» says Sharp.