Sentences with phrase «key cell signaling pathways»

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

Not exact matches

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

But Lonard and O'Malley had a counterintuitive idea: what if they could disrupt key signaling pathways and kill cancer cells by overstimulating SRCs?

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

PNAS June 2009), and he is currently determining the key signalling pathways that mediate lung stem cell growth, quiescence and differentiation.

Elevated levels of the transcriptional regulators TAZ / YAP, key effectors of Hippo pathway signalling, mediate breast cancer cell growth dependence on exogenous glutamine.

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.

Several IFN signaling pathway — related key regulators, including STAT1, STAT2, IRF - 1, and IRF - 9, were transfected individually or in combination into STAT1 - deficient U3A cells, together with a luciferase reporter gene containing RIG - G promoter.

Peerani et al. [31] suggested that there is a minimal colony size effect the maintenance of human ES cell pluripotency, and provided evidence that autocrine regulators of BMP and nodal signaling are key components of this regulatory pathway.

By comparing key biochemical reactions in the cells of fasted and fed scid and B6 mice, the research team was able to identify and describe the highlighted steps (formerly missing links) in the following feeding - induced insulin signaling pathway.

Due to reduced mTOR activity, a key intracellular signaling pathway regulator, the function of the cell's power plants, the mitochondria, is disrupted.