Sentences with phrase «key cellular genes»
This so - called microRNA disrupts the expression of two key cellular genes called TGF - β and SMAD3, in a process known as RNA interference (RNAi).
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«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.
The gene plays a key role in cellular proliferation and is activated in 90 % of all human pancreatic tumors.
The senior researchers of the study, Martin Eilers and Juha Klefström are excited about the concept that Myc's ability to turn off rather than turn on genes is a key to cell death: «It is much easier to bring cellular activities down than up with the existing drugs.
RNA - based gene regulation is revealing itself as key to understanding cellular function, organismal development and homeostasis.
Key to the project are lab and bioinformatics exercises that will give students the unique opportunity to work with Cold Spring Harbor Laboratory researcher David Jackson in determining the cellular analysis of Arabidopsis genes of unknown function.
Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.
«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»
Two key genes were affected in the cellular response to decreased glucose consumption.