New details learned about
a key cellular protein could lead to treatments for neurodegenerative diseases, such as Parkinson's, Huntington's, Alzheimer's, and amyotrophic lateral sclerosis (ALS).
The disruption of the microbiome reduced production of
a key cellular protein vital to the barrier's effectiveness.
Not exact matches
Using the same computer - based approach, the team has now been able to target the c - FLIP (
cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory)
protein, known to play a
key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.
Excitingly, these
proteins are functionally enriched for membrane bending, vesicular biogenesis, and trafficking activities, suggesting that eukaryotes evolved from an archaeal host that contained some
key components that governed the emergence of eukaryotic
cellular complexity after endosymbiosis.
Dr Christos Gkogkas, a Chancellor's Fellow in the University of Edinburgh's Centre for Discovery Brain Sciences, said: «Our study reveals that altered
protein synthesis through eIF4E is a
key cellular process in the brain that can go awry in depression.
Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG,
key proteins in forming the internal
cellular framework that enables and sustains cell division.
Another possibility, Traynor says, is that the repeated nucleotides cause a toxic buildup of messenger RNA, a
key player in the
cellular machinery for reading out DNA to make
protein.
Yang and co-author Chunru Lin, Ph.D., an assistant professor in the same department, confirmed four sites for phosphorylation, a process that turns
protein enzymes off and on, impacting
key cellular functions.
The study, published in Nature Communications today, focused on
protein kinases, enzymes that are
key regulators of
cellular processes.
Although some of the
key molecular components involved in the formation of
cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble
proteins and biophysically characterizing the behavior of large structures and tissues.
Mechanistic target of rapamycin (mTOR) is a
key regulatory
protein that controls the balance between
cellular anabolism and catabolism.
This is why recent work in the field of cancer research has focused on picking apart the complex
cellular pathways involved in the development of different cancers and identifying the roles of
key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.
Proteins work like rigid
keys to activate
cellular functions — or so everyone thought.
The
protein, Argonaute - 2, is a
key player in RNA interference, a powerful
cellular phenomenon that has important roles in diverse biological processes, including an organism's development.
Previously, Walter's team discovered that ISRIB (short for «integrated stress response inhibitor») blocks this aspect of the
cellular stress response by enhancing the activity of a
protein called eIF2B, which helps keep a
key protein production line operating in stressed cells.
First, Nanog opened two
key cellular pathways, known as Rho - associated
protein kinase (ROCK) and Transforming growth factor beta (TGF - β).
Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation
protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a
key homeostatic
cellular process in which dysfunctional or unnecessary
cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions
Is a
key component of various
proteins, as well as enzymes that catalyze
cellular oxidation reactions