Sentences with phrase «key effector»
Antibodies are key effector molecules in health and disease as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses.
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We are currently identifying the downstream effectors of this CAMKK2 - AMPK kinase pathway including Tau and some key effectors of autophagy.
Elevated levels of the transcriptional regulators TAZ / YAP, key effectors of Hippo pathway signalling, mediate breast cancer cell growth dependence on exogenous glutamine.
Tcf3 and Tcf1 are two key effectors in the pathway, and are essential in this process (Lluis et al., PNAS 2011; Ombrato et al., Cell Cycle 2012; Aulicino et al., Stem Cell Report 2014).
Not exact matches
Designed «staple proteins» based on TAL effectors are the key to the method.
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8 + T cells.
IFN - γ production is one of the primary effector functions of activated CD8 T cells in response to LCMV infection, and has been shown to be a key component of mortality in the naive mouse model of FHL2 (8).
Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].
The innate immune system is particularly amenable to characterization with expression - based methodology such as RNA - seq, as one of the key biological consequences of pathogenic infections is the rapid induction of several classes of effector proteins, along with up - regulation of a number of other pathway components.
For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.
For liver transplant - free survival, we identified a genome - wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver - resident effector cells.