Sentences with phrase «key gene in human»

The team sequenced the gene that codes for the NaV1.7 channel in mole rats, and compared it with SCN9A — a key gene in the human version of the channel.

Not exact matches

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.

Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

Readers will have at their fingertips key articles in the history of science from the late 19th through the early 21st centuries, including research about the human genome, breast and colon cancer genes, and the Bose - Einstein condensate in physics.

The investigators also found that the key difference between the two groups lies in the genes involved in production of the bacterium's outer coat, the primary region that interacts with the human immune system.

She notes that a few of the genes the team identified code for glutamate receptors, which play a key role in learning and memory and may have been selected in humans as well.

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

«We couldn't have done this even two years ago,» State said, «because we didn't have the key ingredients: a set of unbiased autism genes that we have confidence in, and a map of the landscape of the developing human brain.

PARIS — As scientists race to finish a rough draft of the human genome, a European consortium is about to launch an effort to pinpoint every key spot in our genetic code where cells turn genes on and off by adding a molecule called a methyl group.

The gene plays a key role in cellular proliferation and is activated in 90 % of all human pancreatic tumors.

A University of Toronto (U of T) study on fruit flies has uncovered a gene that could play a key role in obesity in humans.

Early in human evolution, our ancestors switched off two key genes.

They play a key part in regulating the activity of genes in many species, from yeast to humans Fewer than 10 years ago no one knew they existed

The HLA (human leukocyte antigen) is a system of genes responsible for regulating immune responses, and peptides are short chains of amino acids that play key roles in regulating the activities of other molecules.

The mutation isn't in a region of the gene that codes for the SMARCAD1 protein; instead it's near a key splicing site that prevents SMARCAD1 from being made correctly, the researchers report today in The American Journal of Human Genetics.

But findings presented last week at the Human Genome Meeting in Edinburgh, Scotland, suggest that gene activitynot sequenceholds the key to our identity.

Taking advantage of these «simplified» versions of melanoma, the researchers identified a dozen of new genes that are likely to play key roles in the initiation and / or progression of human melanoma.

Academic scientists are stewing about a recently issued patent that gives a private company the rights to CCR5, a human gene that plays a key role in HIV infection.

In a separate paper, virologist Mark Gibbs and his colleagues at Australian National University in Canberra report that a key gene in the virus that caused the 1918 pandemic is part pig, part humaIn a separate paper, virologist Mark Gibbs and his colleagues at Australian National University in Canberra report that a key gene in the virus that caused the 1918 pandemic is part pig, part humain Canberra report that a key gene in the virus that caused the 1918 pandemic is part pig, part humain the virus that caused the 1918 pandemic is part pig, part human.

The university recently received international attention after a group of 16 scientists based at the Key Laboratory of Gene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fuGene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fugene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.full).

They also found that these culprit genes are involved in various key human neurological functions within the prefrontal cortex, including the transmission of the neurotransmitter GABA across a synapse from one neuron to another.

Marta received the award for her work on the gene ARHGAP11B present only in humans and its key role in the expansion of the neocortex and brain evolution.

The team used genome editing techniques to stop a key gene from producing a protein called OCT4, which normally becomes active in the first few days of human embryo development.

Aug 8, 2008 Two New Predisposition Genes For Breast, Thyroid And Kidney Cancers Could Lead to More Accurate Diagnosis and Earlier Detection of These Cancers Charis Eng, MD, PhD, Sondra J and Stephen R Hardis Endowed Chair of Cancer Genomic Medicine and Chair, GMI, and her team published in the Aug 8, 2008 issue of the American Journal of Human Genetics that germline mutations in SDHB and SDHD, which play key roles in the mitochondria (the cell's power houses), predispose to Cowden and Cowden - like syndromes.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

By determining how changes in gene expression affect the fate of glial cells in mice, we hope to understand the key factors that govern neural cell regeneration in the human brain.

(E) Semi-quantitative RT - PCR analysis of key pluripotency genes expressed in human ES cells and several lacking in human NSCs.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

The 1500 transcription factors (TFs) within the human genome perform a key role in determining the set of active genes within a specific cell, as well as the magnitude of activity.

Over the next decade, he authored key papers predicting the number of genetic markers required for GWAS in humans, and pioneered the field of genetics of global gene expression (eQTL analysis).

Indeed, key aspects of most human disorders can be modeled in experimentally tractable organisms through the analysis of orthologous genes and pathways, using the genetic, biochemical and cell biological toolboxes that have been developed in each model organism.

A protein that appears to play a key role in the formation of lymphoma and other tumors by inhibiting a tumor - suppressing gene has been identified by a team of veterinary and human medicine researchers at the University of California, Davis.

Developed first DNA gene chip for horses housing 3,200 expressed horse genes, helping uncover key differences in genes between humans and animals, giving critical information before launching into an experiment