Sentences with phrase «key gene regulators»
In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.
https://www.sciencedaily.com/ Not exact matches
The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).
Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.
The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.
The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.
«Gene regulator is key to healthy retinal development and good vision in adulthood.»
In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2).
In rice, Oryza sativa HOMEOBOX1, a key regulator of meristem maintenance similar to kn1 from maize, controls local BR accumulation by directly targeting and upregulating genes encoding BR catabolism and conjugation enzymes (Tsuda et al., 2014).
These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.
Several IFN signaling pathway — related key regulators, including STAT1, STAT2, IRF - 1, and IRF - 9, were transfected individually or in combination into STAT1 - deficient U3A cells, together with a luciferase reporter gene containing RIG - G promoter.