Sentences with phrase «key genes involved»

As shown in Figure 1E, all key genes involved in maintaining pluripotency were expressed in hESCs, as expected.

Using comparative genomics analysis, characterization of conserved domains and active sites, and expression analysis, 42 key genes involved in FA biosynthesis in oil palm were identified.

To further investigate additional similarities between hNSCs and hESCs at the transcriptional level, we analyzed the expression of key genes involved in hESC self - renewal and pluripotency utilizing semi-quantitative RT - PCR analysis.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

Scripps Research investigators Richard Klemke (left) and Yingchun Wang want to find the key genes involved in breast cancer metastasis.

What Klemke and Wang want to find are the key genes involved in breast cancer metastasis, and the Komen Foundation grant that Wang received should enable that.

The data allowed the researchers to generate personalized genome - scale metabolic models for cancer patients to identify key genes involved in tumor growth.

Moffitt researchers want to develop a fast, cost - effective blood test that can accurately differentiate low - risk IPMNs that can be monitored from high - risk IPMNs that need to be surgically removed by studying microRNAs (miRNAs), a class of small molecules that regulate key genes involved in the development and progression of cancer.

Indiana University scientists have discovered the first known instance of a plant or animal lacking several key genes involved in energy production in cells.

The authors conclude that the study of marine mammals is just the first demonstration of this new evolutionary approach, and is versatile enough to be applied to many other emerging questions concerning key genes involved in the diversity of life.

According to Beg, NF - κB proteins regulate key genes involved in immune response, inflammation, cell death and cell growth.

It was assumed that these fish became blind because mutations disabled key genes involved in eye development.

We observed strong modulation of key genes involved in lactose synthesis and insulin signaling.

Scientists have for the first time shown how the disruption of a key gene involved in mental illness impacts on the brain.

Not exact matches

Studies involving mice also helped to answer a key question: What turns on the activity of the per and tim genes in the first place?

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

The investigators also found that the key difference between the two groups lies in the genes involved in production of the bacterium's outer coat, the primary region that interacts with the human immune system.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

«It's really cool that they can pinpoint the acquisition of key genes that allow the movement of this bacteria into fleas,» says evolutionary geneticist Hendrik Poinar of McMaster University in Hamilton, Canada, who was not involved with the study.

Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells.

When these birds sing, the activity of a master gene called FoxP2 declines in a key region of the brain involved in vocal control known as Area X.

There are even a few islands — those that contain genes involved in behavior and size, key traits for domesticated animals — that are in the genomes of both European and Asian pigs, Larson reports.

The proof - of - concept study, published online today in the journal Nature, demonstrates that a gene called PGC1 alpha provides kidneys with protection by working through nicotinamide adenine dinucleotide (NAD), a molecule involved in metabolism thought to be key to the aging process.

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

«This higher proportion of genes involved in adaptive (antibody) immunity function could be a key reason behind the infection fighting and fast wound - healing abilities of sharks and rays,» said Professor Stanhope.

«Even more importantly, the differences involved key genes and pathways that are designed to be blocked by new RA treatments.

They also found that these culprit genes are involved in various key human neurological functions within the prefrontal cortex, including the transmission of the neurotransmitter GABA across a synapse from one neuron to another.

Using cutting - edge molecular methods the research team identified 53 key genes that are involved in long - term, multi-generational acclimation to higher temperatures.

A key future experiment will involve attaching a malaria - resistance gene to the Myd88 code engineered to get switched on in the offspring during early development.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

The ortholog genes that were found to be associated with cartilage development, along with bmp which acts as a key member gene, are known to be involved in the Wnt signaling pathway (Kim et al., 2013; Lin & Hankenson, 2011).

Focusing on just these protein - producing genes allows scientists to zero in on mutations that alter key proteins involved in cancer growth.

Key proteins involved in gene expression depend on each other when forming a heart in an embryo, but, if left alone, they start to run amok

The key to this understanding lies with Dll4, one of the earliest known genes involved in artery formation.

Ultimately, we aim to reveal the key species (cultured and uncultivated) involved in dental caries and provide new insights into specific genes / domains, gene products, and metabolic pathways that define the synergistic and competitive contributions to health and disease in this complex microbial community.

By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease.

Our researchers have made key discoveries of the specific gene mutations and proteins involved in both syndromic and non-syndromic congenital sideroblastic anemias, and we have an open research protocol that is helping us to reach our ultimate goal of understanding the genetic basis of all types of CSAs.

One study shows that curcumin turns on a key gene signal involved with nerve protection, which boosts antioxidant enzymes in the brain and helps to prevent neurodegeneration.

Here froggy, froggy Most of «The French Connection» involves action of the moody, low - key sort, with Gene Hackman as Popeye, a no - nonsense, fists - flying detective on the trail of some big - time French drug importers («Frog One» and «Frog Two» as the cops call them) in early - 1970s New York City.

The susceptibility of German shepherds to chronic diarrhoea is not due to a failure of transcription of key genes encoding molecules involved in mucosal IgA secretion In collaboration with scientists at the University of Bristol, UK, WALTHAM investigated a potential cause of the susceptibility of German shepherd dogs to chronic diarrhoea (Peters et al. 2005).