Sentences with phrase «key genes lead»

Not exact matches

Leber congenital amaurosis is caused by a gene defect doesn't lead the retina to make a key protein.

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal.

«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.

Key proteins, produced and regulated by these important genes, activated a cascade of diverse, tissue - specific signals that led to regenerative organ growth.

The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.

During the 1990s, a team led by Jeffery Taubenberger at the Armed Forces Institute of Pathology in Washington, D.C., sequenced key gene fragments of the 1918 flu strain, recovered from frozen victims found in the Alaskan permafrost and in archived autopsy material.

The Jan. 12 issue of the journal Science provides an in - depth and timely review of the key developments that have led to several successful gene therapy treatments for patients with serious medical conditions.

Stice's group has shown that viewing the cake above as too tempting or not tempting enough may lead you down the path to obesity... but your genes are key.

This led Lippman's team to propose that the ancient function of the HPAT genes is to control tip growth, which, Lippman says, is likely related to key proteins that are critical for forming cell walls.

That genetic map led to key insights, such as the link between glioblastoma, the deadliest type of brain tumor, and a gene called BEX1.

deCODE has identified key variations in the sequence of the genome conferring increased risk of major public health challenges from cardiovascular disease to cancer, and employs its gene discovery engine to develop DNA - based tests to assess individual risk of common diseases; to license its tests and intellectual property to partners; and to provide comprehensive, leading - edge contract services to companies and research institutions around the globe.

«This work reveals how a single mutation in a key cardiac gene can lead to at least two forms of disease.»

However, sex differences in regulatory mechanisms of genes could be the key element in explaining sexual dimorphism, leading to variations in phenotype through gene - environment interactions (194).

Aug 8, 2008 Two New Predisposition Genes For Breast, Thyroid And Kidney Cancers Could Lead to More Accurate Diagnosis and Earlier Detection of These Cancers Charis Eng, MD, PhD, Sondra J and Stephen R Hardis Endowed Chair of Cancer Genomic Medicine and Chair, GMI, and her team published in the Aug 8, 2008 issue of the American Journal of Human Genetics that germline mutations in SDHB and SDHD, which play key roles in the mitochondria (the cell's power houses), predispose to Cowden and Cowden - like syndromes.

HIBM is caused by mutations in the gene encoding the key enzyme in sialic acid synthesis, UDP - GlcNAc 2 - epimerase / ManNAc kinase, which in turn leads to sialic acid deficiency.

This study generated more than 5 million datapoints, information that led to the identification of key genes indicative of responsiveness to glucocorticoids.

While not a direct cause of cancer, the researchers suspected that over time this could lead to key anti-tumour genes being damaged that would normally prevent cancer from developing.

They cause an alteration in gene expression, leading to a suppression of key mitochondrial enzymes, like carnitine palmitoyltransferase — which finally solves the mystery of why those eating vegetarian have a 60 % higher expression of that fat - burning enzyme.