Sentences with phrase «key impacts of the changing»

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Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

Vertical integration, consolidation of infrastructure, content production and content distribution have been key trends that could impact how businesses evolve to changing consumer wants and needs.

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share, or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the Company; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; disruptions in information technology networks and systems; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; the Company's dividend payments on its Series A Preferred Stock; tax law changes or interpretations; pricing actions; and other factors.

Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including risks related to new product introductions; risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors; risks associated with BlackBerry's foreign operations, including risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions; risks relating to network disruptions and other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions; risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security risks; BlackBerry's ability to attract and retain key personnel; risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry (R) World (TM); risks related to the collection, storage, transmission, use and disclosure of confidential and personal information;

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, operating in a highly competitive industry; changes in the retail landscape or the loss of key retail customers; the Company's ability to maintain, extend and expand its reputation and brand image; the impacts of the Company's international operations; the Company's ability to leverage its brand value; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share, or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's ability to realize the anticipated benefits from its cost savings initiatives; changes in relationships with significant customers and suppliers; the execution of the Company's international expansion strategy; tax law changes or interpretations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the United States and in various other nations in which we operate; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives we use; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's ability to protect intellectual property rights; impacts of natural events in the locations in which we or the Company's customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; the Company's ownership structure; the impact of future sales of its common stock in the public markets; the Company's ability to continue to pay a regular dividend; changes in laws and regulations; restatements of the Company's consolidated financial statements; and other factors.

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the business and operations of the Company in the expected time frame; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; tax law changes or interpretations; and other factors.

Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including risks related to new product introductions; risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors; risks associated with BlackBerry's foreign operations, including risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions; risks relating to network disruptions and other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions; risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security risks; BlackBerry's ability to attract and retain key personnel; risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry ® World ™; risks related to the collection, storage, transmission, use and disclosure of confidential and personal information; BlackBerry's ability to manage inventory and asset risk; BlackBerry's reliance on suppliers of functional components for its products and risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand; risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products; risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet; risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies; risks related to economic and geopolitical conditions; risks associated with acquisitions; foreign exchange risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry.

These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.

Australia must prepare to respond to the impact of Beijing's stronger commitment of the past 15 years to change through military cyber science and technology in comparison to the Australian government's commitment in key areas of policy.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

«The impact of what the president is doing now will manifest when Nigerians key into his change mantra.»

Professor Bruce Fitt, professor of plant pathology at the University of Hertfordshire's School of Medical and Life Sciences, said: «There is considerable debate about the impact of climate change on crop production — and making sure that we have sufficient food to feed the ever - growing global population is key to our future food security.»

Scientists say reserves can help marine ecosystems and people adapt to five key impacts of climate change: ocean acidification; sea - level rise; increased intensity of storms; shifts in species distribution, and decreased productivity and oxygen availability.

«I think some of the key take - aways from this report, especially compared to the last report, are the impacts of climate change are not just something that we can look towards the future for but they are already occurring today,» said Forbes Tompkins, a research analyst at the World Resources Institute who has been tracking the report.

Environmental scientists and synthetic biologists have for the first time developed a set of key research areas to study the potential ecological impacts of synthetic biology, a field that could push beyond incremental changes to create organisms that transcend common evolutionary pathways.

Balancing the impacts of various technologies is key to tackling climate change.»

One of the report's lead authors, Monash University Professor Steven Chown, said key areas for scientific research in the region over the next two decades included looking at human impact on the region, understanding the evolution of Antarctic life, looking at the region's history, and the impact of climate change in the area.

Still, Ogden noted, a number of key issues central to the 2015 agreement remain unresolved — like what legal form the deal will take, how countries will prove they are making progress on mitigation targets and how much money wealthy nations will pony up to help poorer ones cut carbon and prepare for the impacts of climate change.

«Deep - sea biodiversity impacted by climate change's triple threat: Researchers find a key effect of oxygen loss and that climate change impacts vary by region.»

«A key premise of this commitment is that adaptation planning needs to be informed by a continuing scientific, sound assessment of the impacts of a changing climate and the effectiveness of preparations and response options,» Abbott said.

Research at the University of Edinburgh first created a simple algorithm to determine the key factors shaping climate change and then estimated their likely impact on the world's land and ocean temperatures.

It is important because understanding the cause - and - effect cascade of changes to ecosystems is key to anticipating impacts of human actions and minimizing damage to natural systems that undergird our planet's ability to support human life.

«Our finding that vegetation plays a key role future in terrestrial hydrologic response and water stress is of utmost importance to properly predict future dryness and water resources,» says Gentine, whose research focuses on the relationship between hydrology and atmospheric science, land / atmosphere interaction, and its impact on climate change.

Key weather and climate drivers of health impacts include increasingly frequent, intense, and longer - lasting extreme heat, which worsens drought, wildfire, and air pollution risks; increasingly frequent extreme precipitation, intense storms, and changes in precipitation patterns that lead to drought and ecosystem changes (Ch.

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

For the assessments of climate impacts made herein, we follow guidance from the National Climate Assessment and Intergovernmental Panel on Climate Change (IPCC) on how to standardize confidence levels and uncertainty characterization in our key messages, as provided below.

This information is used throughout the assessment to explain the key impacts of climate change observed in recent decades and projected in the future.

As I have said, small changes are key, and following this diet will certainly teach you the importance of making these small changes, and how big of an impact it can have on your life.

The Center last conducted a detailed survey of the internet's impact on dating and relationships in 2005, and a primary goal of this study is to update key trends on the internet and dating — such as the overall prevalence of online dating, how attitudes towards online dating have changed over time, and whether or not more people are meeting online than in the past.

In order to remove the confounding influence of unobserved factors that have an impact on both school spending and student outcomes, we calculate how much spending in a given school district would have been predicted to change due solely to the passage of an SFR, and use that prediction, rather than the spending change the district actually experienced, as our key variable.

The two key elements of a radically different world that impact education are 1) access to information, and 2) the rate of change.

Studies of human and physical geography continue at key stage three, where the impact of humans on changes to the environment and climate can be covered in more depth.

The education secretary has in her grasp some key levers to head off the perfect storm that is beginning to gather: in seeking information, before the election, about the workload challenges facing schools, she knows that: Ofsted needs extensive reform, possibly replaced with validated peer - to - peer accountability and the incoherent sequencing and pace of curriculum changes need to be rethought with school leaders thinking about what will have a significant impact on children's learning.

The evaluation focused on three key areas: 1) Implementation (training, staffing, promotion, availability, methods for sustainability, curricular connections), 2) Participation (methods of adoption / education, level of participation, parent / teacher / food service worker roles) and 3) Attitudes (changes in diet / nutrition - related knowledge, behavior, impact of cultural differences, food likes / dislikes, expectations, influences on food selection, etc.).

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Spoke Light Alloy Wheels (Style 426)- Inc: P245 / 45R19 Run - Flat All - Season Tires Led Fog Lights Automatic Trunk Lid Open / Close Xenon Rain - Sensing Adaptive Headlights - Inc: Dynamic Auto - Leveling Corona Headlight - Rings & Cornering Lights Retractable High - Intensity Headlight Washers Body - Color Exterior Door Handles Adaptive Brake Lights Pathway Lighting Feature Programmable Via Vehicle & Key Memory Power Soft - Close Automatic Doors Dual Cupholders Front & Rear Front Visors W / Illuminated Vanity Mirrors Dynamic Cruise Control Expanded Check Control Vehicle Monitor System Power Windows - Inc: Key - Off Operation One - Touch Open / Close Anti-Trapping Feature Coded Driveaway Protection Ambiance Lighting In Front Rear & Door Panels Dual Illuminated Rear Vanity Mirrors Integrated Into Rear Cabin Roof Lining Vehicle & Key Memory Fully Finished Trunk Comfort Access Keyless Entry W / Multi-Function Remote Rear Center Armrest W / Storage Compartment Rear Window Defogger Auto - Dimming Rear - View Mirror 4 - Zone Automatic Climate Control - Inc: Draft - Free Vents Solar Sensor Automatic Recirculation Heat - At - Rest Feature Automatic Ventilation Electronic Analog Speedometer & Tachometer Anti-Theft Alarm System - Inc: Interior Motion Detector Owner's Manual Condition - Based Service Display W / Additional Functions Accessible Through Idrive System Central Power Locking System - Inc: Anti-Theft Feature Selective Unlocking Programmable Via Vehicle & Key Memory Nappa Leather Upholstery Black Panel Display W / Lcd Main & Trip Odometer Displays & Warning Indicators In Dial Faces Front & Rear Floor Mats Hard Drive - Based Navigation System - Inc: Voice - Command & Real Time Traffic Info Fineline High Gloss Wood Interior Trim Power Tilt / Telescoping Steering Column Remote Trunk Release Heated Front Seats W / Fast Heating & Balance Control Front Console Compartment - Inc: Coinholder Illumination Multi-Contour 20 - Way Power Front Bucket Seats - Inc: 4 - Way Pwr Lumbar Support Articulated Upper Backrest Adjustable Backrest Width Adjustable Thigh Support Driver & Front Passenger Seat Memory Active Head Restraints W / Adjustable Side Support Integrated Universal Garage Door Opener Multi-Function Sports Leather - Wrapped Steering Wheel - Inc: Audio Controls Phone Controls 2 - Position Memory Smokers Pkg Idrive System - Inc: On - Board Computer Controller (8) Programmable Memory Buttons 8 - Speed Automatic Transmission - Inc: Automatic & Manual Shift Modes Both W / Fully Synchronized Electronic Gear Changes Self - Leveling Air Spring Rear Suspension Rear Wheel Drive 4.4 - Liter Twinpower Turbo 32 - Valve 445 - Hp V - 8 Engine - Inc: Double - Vanos & Valvetronic Variable Valve Control High - Precision Direct Injection Dynamic Damping Control Driving Dynamics Control Front Multi-Link Double - Wishbone Aluminum Suspension Rear Multi-Link Integral - V Aluminum Suspension Brake Energy Regeneration To Convert Kinetic Energy Into Usable Electrical Pwr 4 - Wheel Ventilated Disc Brakes W / Electronic Brake Proportioning Twin - Tube Gas - Pressure Shock Absorbers Vehicle - Speed - Sensitive Variable - Assist Variable - Ratio Rack - & - Pinion Power Steering Auto Start - Stop Function Aluminum Front & Rear Subframes Electromechanical Parking Brake ** Preliminary Standard Equipment ** Front - Seat Side - Impact Airbags 3 - Point Safety Belt System - Inc: Alr In All Passenger Positions Rear - View Camera Child Safety Rear Door Locks Anti-Lock Braking System (Abs) Driver & Front Passenger Dual - Threshold Dual - Stage Front Airbags W / Passenger Occupant Sensor Front & Rear Head Protection System (Hps) Corona Ring Integrated Daytime Running Lights Front & Rear Park Distance Control W / Graphic Display Emergency Interior Trunk Release Handle Front Safety Belt Automatic Pretensioners Acoustic Belt Warning Active Protection Bmw Assist W / Enhanced Bluetooth & Usb - Inc: (4) Years Of Automatic Collision Notification Emergency Request Enhanced Roadside Assistance Remote Door Unlock Stolen Vehicle Recovery Customer Relations Teleservice Mobile Office Features Myinfo Lower Anchors & Tethers For Children (Latch) On Rear Outboard Seats Dynamic Stability Control (Dsc)- Inc: Brake Fade Compensation Start - Off Assistant Brake Drying Brake Stand - By Dynamic Traction Control (Dtc) Dynamic Brake Control Crash Sensor That Activates Battery Safety Terminal Disconnect Of Alternator Fuel Pump & Starter From Battery Automatically Unlocks Doors Turns On Hazard & Interior Lights Tire Pressure Monitor Active Knee Protection

Key suspension changes include the first Altima application of monotube rear shocks, added suspension reinforcements to improve vehicle response without impacting harshness, and suspension geometry adjustments to improve steering feedback.

1 Block South of Fox Valley Mall west of Rt. 59 on Ogden Ave. Options: 6 Speakers Am / Fm Radio: Siriusxm Cd Player Mp3 Decoder Radio: Autonet Am / Fm / Cd / Mp3 Audio System Air Conditioning Automatic Temperature Control Dual Front Automatic Temperature Control Front Dual Zone A / C Rear Window Defroster 60/40 Split Fold - Down Rear Seatback Outside Temperature Display Power Driver Seat Power Steering Power Windows Remote Keyless Entry Steering Wheel Mounted Audio Controls Tire Pressure Monitoring System Four Wheel Independent Suspension Sachs Premium Shock Absorbers Speed - Sensing Steering Traction Control 4 - Wheel Disc Brakes 4 - Wheel Disc Brakes W / Abs Abs Brakes Advanced Front Airbags Anti-Whiplash Front Head Restraints Dual Front Impact Airbags Dual Front Side Impact Airbags Front Anti-Roll Bar Hillstart Assist Control (Hac) Low Tire Pressure Warning Occupant Sensing Airbag Overhead Airbag Power Door Locks Proximity Key Entry W / Push - Button Start Rear Anti-Roll Bar Brake Assist Electronic Stability Control Electronic Stability Control W / Traction Control System Ez Lane Change Assist Automatic Headlights Delay - Off Headlights Fog Lights Front Fog Lights Fully Automatic Headlights Panic Alarm Remote Keyless Entry System W / Alarm Security System Speed Control Steering - Wheel Mounted Audio & Cruise Controls Body - Color Heated Manual Folding Power Mirrors Bodycolor Rear Spoiler W / Led Brake Lights Bumpers: Body - Color Chrome Accent Grille & Door Handles Engine Cover Heated Door Mirrors Lower Bodyside Cladding Power Door Mirrors Premium Door Sill Plates Roof Rack: Rails Only Spoiler Turn Signal Indicator Mirrors Auto - Dimming Mirror W / Homelink Auto - Dimming Rear - View Mirror Driver Door Bin Driver Vanity Mirror Front Reading Lights Garage Door Transmitter: Homelink Illuminated Entry Illuminated Vanity Mirrors & Glove Compartment Leather Shift Knob Leather - Wrapped Shift Knob Leather - Wrapped Steering Wheel Multi-Function Trip Computer Outside Temperature Display Overhead Console Passenger Vanity Mirror Rear Seat Center Armrest Tachometer Telescoping Steering Wheel Tilt & Telescopic Steering Wheel Tilt Steering Wheel Trip Computer Active Front Head Restraints Front Bucket Seats Front Center Armrest Front Seatback Pockets Heated Front Bucket Seats Heated Front Seats Leather Seat Trim Split Folding Rear Seat Passenger Door Bin Retractable Cargo Cover Silver Roof Side Rails 18 X 6.5 Alloy Wheels Driver Power Window W / Auto Up / Down Rear Privacy Glass Rear Window Wiper W / Washer Solar Front Glass Variable Intermittent Front Windshield Wiper Rear Window Wiper Variably Intermittent Wipers Windshield Wiper De-Icer 3.195 Axle Ratio

Risks and uncertainties include without limitation the effect of competitive and economic factors, and the Company's reaction to those factors, on consumer and business buying decisions with respect to the Company's products; continued competitive pressures in the marketplace; the ability of the Company to deliver to the marketplace and stimulate customer demand for new programs, products, and technological innovations on a timely basis; the effect that product introductions and transitions, changes in product pricing or mix, and / or increases in component costs could have on the Company's gross margin; the inventory risk associated with the Company's need to order or commit to order product components in advance of customer orders; the continued availability on acceptable terms, or at all, of certain components and services essential to the Company's business currently obtained by the Company from sole or limited sources; the effect that the Company's dependency on manufacturing and logistics services provided by third parties may have on the quality, quantity or cost of products manufactured or services rendered; risks associated with the Company's international operations; the Company's reliance on third - party intellectual property and digital content; the potential impact of a finding that the Company has infringed on the intellectual property rights of others; the Company's dependency on the performance of distributors, carriers and other resellers of the Company's products; the effect that product and service quality problems could have on the Company's sales and operating profits; the continued service and availability of key executives and employees; war, terrorism, public health issues, natural disasters, and other circumstances that could disrupt supply, delivery, or demand of products; and unfavorable results of other legal proceedings.

During this webcast, we covered: • Our proprietary portfolio management process • Personnel changes made in 2015 and the people managing the Fund • Key objectives over the last few years and their impact on current performance • Fund performance YTD • Fund outlook for the 2nd half of 2017 & beyond

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Some of the most important changes center on key deductions and credits that could have a significant impact on the younger generation of taxpayers.

To ensure our activities are having an impact towards our overall 2020 mission goals we track the following key measures: # researchers funded, breakthrough achievements of funded research, policies changed and / or significant progress made on healthy public policies, # Canadians reached to learn about and establish healthy lifestyle choices and, # survivors and care partners reached to receive needed information and supports.

We work collaboratively and cooperatively with key stakeholders based on the premise that we can have a greater impact creating positive change by being a part of the process instead of being apart from it.

The federation works collaboratively and cooperatively with key stakeholders based on the premise that it can have a greater impact creating positive change by being a part of the process instead of being apart from it.

Apparently, it will be possible for the player to lose members of their squad as they play through the game, which will also have an impact on the kind of help they'll be able to receive: «You can be separated from guys with key abilities that would change how you play — if you're not with the ammo guy then you have less ability to replenish your ammo.»

Dr. Jablonski added, «There's a key difference between the potential impact of climate change now versus in the past.