Sentences with phrase «key inflammatory cytokines»

We show that inoculation of mice with DENV NS1 alone induces both vascular leakage and production of key inflammatory cytokines.

Not exact matches

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

These changes are important because both stressors and depression can sensitize the inflammatory response in such a way that they produce heightened responsiveness to stressful events as well as antigen challenge.25, 27,28,60 Furthermore, more frequent or persistent stress - related changes in plasma levels of these key cytokines have broad implications for health; elevated levels of proinflammatory cytokines have been linked to a variety of age - related disease, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 Moreover, inflammatory activation can enhance development of depressive symptoms.30, 31 Thus, relationships characterized by hostility, repeated conflicts, and heightened IL - 6 levels could have negative consequences for both physical and mental health.