Sentences with phrase «key mechanism with»

These cosmic impacts are also the key mechanism with which life, or at least its chemical building blocks, are delivered between worlds, according to the panspermia hypothesis which posits that the seeds of life are common throughout the Universe and can be spread from planet to planet by cometary and asteroid impacts.

Not exact matches

M&A will never be 100 % successful and we learn from every deal we do, and so not to pick on any specific deal, but I've learned, based on relative success of deals we've done in the past, is making sure the key leaders at the company share a vision with the founder, making sure the strategy drives the M&A, as opposed to the M&A driving the strategy, and making sure we have good support mechanisms for these companies after they come in.

Though the researcher said there needs to be more research into the exact mechanisms of why that is, they concluded that «healthy sleep appears to play an important role in maintaining brain health with age, and may play a key role in [Alzheimer's disease] prevention.»

While difficult for those with travel or business expenses in U.S. dollars, the lower exchange rate is a key mechanism of adjustment for the Canadian economy.

The future of research into the potential health benefits of cocoa should focus on the mechanisms and active compounds, with well defined clinical trials key to this burgeoning segment, says a new review by Nestlé.

Indeed, many consider the development of emotional self - regulation in particular to be one of the key processes in childhood behaviour problems.27, 28,29,30 For example, in characterizing the behaviour of children with early externalizing behaviour problems, there is often reference to a lack of control, under - control, or poor regulation.29, 30 In characterizing the behaviour of children with internalizing disorders, there is often a discussion of over - control.12 Understanding the role of temperament in child development may be facilitated by examining the possible mediational effects of emerging self and emotion regulation, and may provide a more proximal mechanism for the development of different forms of behavioural adjustment difficulties characteristic of childhood.

«This is wonderfully serendipitous — our drug just happens to be able to overcome both of the biological mechanisms that are key to survival of aggressive lymphoma,» Dr. Melnick says, adding that the inhibitor completely eradicated DLBCL in mice in a short time, with no detectable side effects.

So far scientists do not understand the underlying mechanisms, but if bird brains share certain key circuits with humans, then scientists may find answers by studying them.

«We need to design nanoparticles that will, like a lock - and - key mechanism, travel through the body and interact only with the diseased cell surface,» says Marth.

It has been used to make a bewildering variety of objects, from toothed gears to 3D boxes with a lock - and - key mechanism.

«Confronted with sepsis, key immune mechanism breaks, scientists find.»

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

New research from a team led by Wolf Frommer, director of the Plant Biology Department, Carnegie Institution for Science in Stanford, in collaboration with the Carter lab in Minnesota and the Baldwin lab at the Max Planck Institute for Chemical Ecology in Jena, Germany, now identified key components of the sugar synthesis and secretion mechanisms.

Scientists from The University of Manchester working with IBM Research have identified a key biological mechanism that for the first time explains why women with dense breast tissue are at greater risk of developing breast cancer.

Richard H. Scheller (Genentech) and Thomas C. Südhof (Stanford University School of Medicine) identified and isolated many of this reaction's key elements, unraveled central aspects of its fundamental mechanism, and deciphered how cells govern it with extreme precision.

Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging.

The next major advance which moved this analysis from a cell physiological to a molecular level was accomplished by Scheller and Südhof who made overlapping contributions that characterized the proteins that controlled the two key steps of transmitter release: 1) They showed the mechanism by which the vesicle is mobilized to the release sites of the presynaptic terminal, where the synaptic vesicle first fuses with the membrane of the sending neuron and then leaves the cell, and 2) they also discovered how Ca2 + drives the vesicle to release its contents.

NIH scientists have discovered a mechanism involved in stabilizing key HIV proteins and thereby concealing sites where some of the most powerful HIV neutralizing antibodies bind, findings with potential implications for HIV vaccine research.

We postulate that HD mutant hPSC (embryonic or induced) lines can constitute such models and would be key to the exploration of the molecular mechanisms of the disease and ultimately allow the screening of therapeutic compounds endowed with a therapeutic potential.

This Program is based on the idea that supporting key individuals is a critical mechanism for achieving high impact science that will lead the field forward with new concepts, technologies, methods, and more.

Researchers in the laboratory of Whitehead Member Susan Lindquist have identified a key mechanism that enables pathogenic fungi to evolve drug - resistant capabilities with such distressing rapidity.

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

With collaborators in the biology department, Dr. Weiss applied these ultrasensitive techniques to investigate the Hedgehog signaling pathway — a critical mechanism that helps give rise to the spatial patterning in developing embryos, but has also been identified as a key culprit in up to 25 % of cancer deaths.

At USCF, Walter began the work that might prove to be his enduring legacy — the discovery of a key element in a quality control mechanism that cells deploy to deal with stress related to the buildup of misfolded proteins in the ER.

The project has the potential to provide important new information about mechanisms of drug resistance in melanoma - a key medical problem - as well as to evaluate the potential of splicing inhibitors as a therapeutic approach in two groups of melanoma pts with different response kinetics.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

The SFI Partnership Schemes aim to provide a flexible mechanism by which SFI can build strategic collaborations with key partners such as industry, funding agencies, charities, philanthropic organisations or higher education institutes (HEIs) with the goal of co-funding outstanding opportunities.

While this concept of epigenetic germline inheritance has long been met with skepticism, evidence in support of this route of information transfer is now overwhelming, and some key mechanisms underlying germline transmission of acquired information are emerging.

Engaging with industry remains one of the key mechanisms for transferring the benefits of public investment in research into sustainable economic development and creating competitive advantage for Ireland.

Our lab is focused on delineating the mechanisms underlying these key GSC tumorigenic properties with a long - term goal of uncovering potential therapeutic targets.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

Travel can seriously mess with key mechanisms of oral contraceptives such as The Pill, rendering travellers susceptible to unplanned pregnancy.

Earlier lab work by the researchers helped explain key mechanisms involved with assisting vitamin D3 to clear the abnormal protein amyloid - beta, which is found within the plaque.

The relationship between FOXO1 and the sirtuins, both of which are inhibited by insulin receptor signaling, may be the key mechanism behind the life - extending effects of calorie restriction with adequate nutrition (CRAN).

Long before mechanical biofeedback techniques emerged, natural biofeedback mechanisms were built into our nervous systems — a key feature in our development with early humans using it instinctively for survival.

Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and allelic frequencies between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established.

This allows me to understand the approach taken in conventional medicine, enables me to read blood work and essentially leverage the best of what modern science can offer, while working with the body's natural healing mechanisms and using therapeutic nutrition as the key to healing.

The mechanism by which an underactive thyroid causes weight gain — or an inability to lose weight — isn't well understood, but it has to do in part with several key factors:

Given her hands - off approach and Vincent's determination, the mechanism for the story's development still feels a bit too clumsy: all it takes for Vincent's wishes to come true is for Marie to stumble upon his room one day, flirt ever so slightly with him, and then steal doc's car keys.

Gewertz identifies the key components of the program as being how they are funded, whether states are clear with districts about student eligibility to participate, and whether mechanisms are in place to ensure rigor.

The overall goal of this extension of our existing work in partnership with TFF and Achievement First Bridgeport Academy (AFBA) is to continue and expand our work in Bridgeport focusing in several keys areas: (1) building knowledge about (a) children's emerging skills and areas of challenge in the social - emotional domain and why these skills are critical to school success, and (b) the ways in which adult stress and skills in the social - emotional domain can impede or foster children's social - emotional skill development; (2) identifying, deploying, and evaluating strategies to build adult and child skills in social - emotional learning with an emphasis on the Tauck Family Foundation's (TFF) five essential SEL skills; and (3) developing and testing a performance management system for SEL that (a) guides the identification of strategies, (b) provides a mechanism for ongoing progress monitoring, feedback, and changes to practice, and (c) serves as an anchor point for ongoing coaching and support in using SEL strategies.

The proposed legislation, which hits the House floor this afternoon, would have two key effects: prohibit the possibility of engaging in a new, substantial mechanism to compare NC students» academic performance with that of students in other states; and authorize the creation of a review commission composed of parents, educators, and other stakeholders to review alternative standards and recommend them for adoption.

An electronic key fob — a small hardware device with built - in authentication mechanisms — will then be sent to the owner.

1/8 turn style; Pressure vacuum type for emission control; Includes 2 keys; With quality lock cylinder; Made from sturdy and long life materials; Features locking mechanism that deters fuel theft and vandalism; Equipped with carefully designed and tested pressure and vacuum relief valves to maintain a specified amount of pressure or vacuum in the tank before relieving; Provides fuel economy and reduces fuel emission; Protects vehicle occupants from gasoline vapors; With 90 - day Stant limited warraWith quality lock cylinder; Made from sturdy and long life materials; Features locking mechanism that deters fuel theft and vandalism; Equipped with carefully designed and tested pressure and vacuum relief valves to maintain a specified amount of pressure or vacuum in the tank before relieving; Provides fuel economy and reduces fuel emission; Protects vehicle occupants from gasoline vapors; With 90 - day Stant limited warrawith carefully designed and tested pressure and vacuum relief valves to maintain a specified amount of pressure or vacuum in the tank before relieving; Provides fuel economy and reduces fuel emission; Protects vehicle occupants from gasoline vapors; With 90 - day Stant limited warraWith 90 - day Stant limited warranty.

This program identifies key work zones that will require an enhanced TMP, with components such as work zone ITS, limited construction hours, night work, lane rental contracting mechanisms, and Traffic Incident Management (TIM) plans.

An issue with the micro switch inside the shifter mechanism could cause a problem where the ignition key will be hard to remove because it won't turn into the OFF position.

It is not that the polar regions are amplifying the warming «going on» at lower latitudes, it is that any warming going on AT THE POLES is amplified through inherent positive feedback processes AT THE POLES, and specifically this is primarily the ice - albedo positive feedback process whereby more open water leads to more warming leads to more open water, etc. *** «Climate model simulations have shown that ice albedo feedbacks associated with variations in snow and sea - ice coverage are a key factor in positive feedback mechanisms which amplify climate change at high northern latitudes...»

«Climate model simulations have shown that ice albedo feedbacks associated with variations in snow and sea - ice coverage are a key factor in positive feedback mechanisms which amplify climate change at high northern latitudes...»

«I look forward to seeing improvement and enhanced collaboration with key partners on the cornerstones of progressive energy policies and other important mechanisms for advancing the clean energy transitions.»

«A key heat storage mechanism, they say, is the «conveyor belt» current that moves salty tropical water to the North Atlantic, where it sinks, carrying heat with it.»