Sentences with phrase «key molecules involved»

We also demonstrate the inhibitory effect of kahweol on the endothelial cell potential to remodel extracellular matrix by targeting two key molecules involved in the process, MMP - 2 and uPA.

Altogether, our results demonstrate that kahweol is a potent anti-angiogenic compound both in vitro and in vivo, targeting some key steps shared with tumor progression, key molecules involved in ECM remodeling (MMP - 2 and uPA), and key molecules involved in inflammation (COX - 2 and MCP - 1).

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

Not exact matches

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

The proof - of - concept study, published online today in the journal Nature, demonstrates that a gene called PGC1 alpha provides kidneys with protection by working through nicotinamide adenine dinucleotide (NAD), a molecule involved in metabolism thought to be key to the aging process.

The key to the drug's potential involves a molecule the body produces that is known as prostaglandin E2, or PGE2.

Jules Hoffmann of the University of Strasbourg in France first identified a key molecule, called Toll, involved in the innate immune response in fruit flies.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

Moffitt researchers want to develop a fast, cost - effective blood test that can accurately differentiate low - risk IPMNs that can be monitored from high - risk IPMNs that need to be surgically removed by studying microRNAs (miRNAs), a class of small molecules that regulate key genes involved in the development and progression of cancer.

Research in the lab of Edward P. Feener, Ph.D., Investigator in the Section on Vascular Cell Biology and Director of the Proteomics Core at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, now has shown that a substantial percentage of patients with DME do not have high levels of VEGF in the fluid inside their eyes but do have high levels of a protein called PKal (plasma kallikrein) and associated molecules that are key players in an inflammatory molecular pathway involved in the disease.

For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systems.

La Jolla, CA — A molecule found in nearly all cells plays a vital role in kick - starting the production of key biological molecules involved in inflammation, a group of Salk Institute scientists has discovered.

You'll find out what DNA code represents, how it creates proteins inside the body, and what key molecules are involved.

Although some of the key molecular components involved in the formation of cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.

La Jolla, CA — A molecule found in nearly all cells plays a vital role in kick - starting the production of key biological molecules involved in inflammation, a group of Salk...

Another key contribution made to the field is Schreiber's formal planning of diversity - oriented synthesis (DOS), which involves the creation of diverse libraries of small molecules for biological screening.

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

On the next slide I show you basically the key domain that's involved in this signaling interaction, so when the insulin receptor is phosphorylated, in order to recruit adaptors such as IRS - 1, it uses an important domain called the PTP domain, or phosphotyrosine containing peptides that can actually mediate this interaction, and lead to the interaction of these various molecules within the pathway.

An antibody therapy against a key inflammatory molecule involved in migraines reduces the number of headaches that chronic migraine patients experience per month in a phase III trial A new s...

A key step in this process involves being able to tether the DNA to various surfaces and stretch the molecule to varying lengths.

* It's also involved in the production of several key enzymes that are used to create adenosine triphosphate, or ATP, a key energy storage molecule.

The susceptibility of German shepherds to chronic diarrhoea is not due to a failure of transcription of key genes encoding molecules involved in mucosal IgA secretion In collaboration with scientists at the University of Bristol, UK, WALTHAM investigated a potential cause of the susceptibility of German shepherd dogs to chronic diarrhoea (Peters et al. 2005).