Curcumin activates PPAR (peroxisome proliferator - activator receptor) which is a group of
key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream.
Not exact matches
These 10 sets encode
proteins responsible for four related bioenergetic processes:
nuclear - encoded mitochondrial electron transport (the
key energy - extracting operation), mitochondrial biogenesis (by which new mitochondria are formed) as well as glucose utilization and glucose sensing (processes by which glucose levels are evaluated and modified).
In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a
key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related
proteins such as Ras,
nuclear lamins and insulin - like growth factor receptors.
They also found that a
protein called Seven in absentia 2 (Siah2) is a
key regulator of the turnover of a well - studied, clock
nuclear protein called RevErbα on a 24 - hour cycle.
The jammed up
nuclear pores reopened, they report, and
key proteins once again moved into the nucleus.
Known
key pathological mechanisms are related to defects in structural
proteins,
nuclear proteins, intermediate filaments and other cyoskeletal
proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.
In a study featured on the cover of Nature Structural and Molecular Biology, investigators in Science Park faculty member Dr. Snow Shen's lab uncovered one of the
protein's
key nuclear functions.