Sentences with phrase «key pathways»

Basically, there are a number of key pathways that regulate metabolism, but leptin and insulin signaling are really important.

«But it appears the key may be to combine it with other drugs to shut off multiple key pathways in those tumors,» she adds.

Many of these new drugs promise to be more effective because they target key pathways of cancer cells more specifically.

In addition, they discovered disturbances in neural circuits that define key pathways between parts of the cerebral cortex.

One key pathway for neurotransmitter production that is highly influenced by the microbiota is the metabolism of the amino acid tryptophan.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

The December 2011 e-publication AMP - activated protein kinase (AMPK) controls the aging process via an integrated signaling network makes the point that control of Nrf2 along with control of other key pathways by AMPK drives aging.

Figure 5 shows how key pathways are altered in luminal (first % box) and basal (middle box) breast cancer and ovarian cancer (right box).

The SIGMA project aims to develop novel biomedical approaches to treat this devastating disease by applying powerful sequencing technologies to discover the genes and key pathways underlying common varieties of cancer.

«Intuitively, one might expect disease - causing variants to cluster into key pathways that drive disease etiology [the causes of disease],» they write.

Curcumin has potent antioxidant benefits and has been shown to support key pathways involved in healthy cell growth, cell maturation, and inflammation.

The reason this is problematic is that Roundup damages several key pathways by which the human body processes and absorbs nutrients.

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

Somatic mutations affect key pathways in lung adenocarcinoma Nature, 455 (7216), 1069 - 1075 DOI: 10.1038 / nature07423

I am a very proud Ghanaian today and I thank the President for following one of the key pathways to dealing with Winner - Takes - All politics.

Two new members of a key pathway responsible for pattern formation during vertebrate development have been identified.

OMP - 54F28 (FZD8 - Fc) and a sister compound also developed by OncoMed, vantictumab (OMP - 18R5), are two of the first therapeutic agents targeting this key pathway to enter clinical testing.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

«Our work shows that L - arginine is a critical component in regulating a key pathway that promotes blood vessel development in the placenta.

By identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.»

«Once we can understand what the key pathways are that cause this variability, we can start to think about targeting those pathways, to combat alternate outcomes in cancer treatment, for example.»

«We're now trying to track down which the key genes are, and which the key pathways are,» she says.

The researchers also identified several cases with gene fusions involving the gene BCAR4, which produces a long noncoding RNA that has been shown to induce responsiveness to lapatinib, an oral drug that inhibits a key pathway in breast cancer.

By mapping the key pathways active in prostate cancer cells, the researchers were able to identify the «master switches» in those pathways that could be targeted with drugs to disrupt the disease.

«One end of the molecule binds to p110 forming a key pathway that is needed for the metabolic effects of insulin on glucose metabolism.

We have used the information gained from these studies to identify key pathways and mechanisms involved in tumor resistance to chemotherapy and radiation, including the role of colorectal cancer stem cells.

Research aiming at understanding mechanisms and key pathways of disease will in future improve the early detection, diagnosis and treatment of respiratory diseases.

Parsley helps to stimulate most of our key pathways of detoxification, including our bowels, our lungs, liver, kidneys and spleen.

Further, growing research also implicates mitochondrial dysfunction as a key pathway in the development of neurodegenerative diseases.

It is expected that 90 per cent of all future jobs will require digital skills and it is estimated that the UK will need more than 1.2 million new technical and digitally skilled people by 2022 to satisfy future skills needs, computer science GCSE is one of the key pathways that young people can take.

It is expected that 90 % 1 of all future jobs will require digital skills and it is estimated that the UK will need more than 1.2 million new technical and digitally skilled people by 20222 to satisfy future skills needs, Computer Science GCSE is one of the key pathways that young people can take.

So, addressing this problem may be a key pathway to reducing global emissions and fighting climate change.

A key pathway for drought acclimation involves abscisic acid (ABA) signaling to recruit drought defense responses which result in stomatal closure, thereby regulating plant water consumption (Shinozaki and Yamaguchi - Shinozaki 2007, Popko et al. 2010, Raghavendra et al. 2010).