Sentences with phrase «key pathways by»

The reason this is problematic is that Roundup damages several key pathways by which the human body processes and absorbs nutrients.

The December 2011 e-publication AMP - activated protein kinase (AMPK) controls the aging process via an integrated signaling network makes the point that control of Nrf2 along with control of other key pathways by AMPK drives aging.

Not exact matches

The Accountability Framework, an initiative being developed by a coalition of leading environmental and social organisations (including the Rainforest Alliance), will provide a clear pathway for companies on the sustainability journey — including key milestones and benchmarks to evaluate their progress.

Key brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effeKey brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effekey neurochemical pathways bringing about the possibility of using drugs to block the nocebo effect.

OMP - 54F28 (FZD8 - Fc) and a sister compound also developed by OncoMed, vantictumab (OMP - 18R5), are two of the first therapeutic agents targeting this key pathway to enter clinical testing.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last weeBy giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last weeby 15 %, they reported last week.

In addition, he touted the benefits of international research cooperation as a key pathway to innovation — a theme echoed by Moniz.

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

A fourth study finds that a generalized seizure leads to diminished short and long - term memory by interfering with key signaling pathways in the brain.

The retrograde response pathway is specific to the yeast used in the study and supplies key amino acids to the cell by changing the metabolic process of the mitochondria.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

Researchers at Houston Methodist have solved a 100 - year - old mystery, providing them a possible key to unlock a pathway for treating diseases caused by flesh - eating bacteria.

By identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.&raquBy identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.&raquby age in mice we have a better idea of what to look for in humans.»

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

The team discovered that the TCL1 protein played a key role in increasing glycolysis by activating a different metabolic pathway that is important for the self - renewal of stem cells.

«Even more importantly, the differences involved key genes and pathways that are designed to be blocked by new RA treatments.

EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.

In the first clinical proof of its kind, a drug has dramatically shrunk cancerous tumors by disrupting a key genetic pathway.

But Lonard and O'Malley had a counterintuitive idea: what if they could disrupt key signaling pathways and kill cancer cells by overstimulating SRCs?

A key step in many signaling pathways is «phosphorylation,» the activation or deactivation of a protein by adding a phosphate group at certain sites on the protein.

The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.

«We have found steroids also suppress inflammation by upregulating IRAK - M, a key negative regulator of inflammatory pathways,» Li said.

This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.

Mammalian cells treated with Mcf1 also display key features of apoptosis which is putatively mediated by a BH3 - like domain and involves the mitochondrial pathway [24], [25].

The transcriptomics and phosphoproteomics data generated by this project will allow the identification of novel host and parasite genes and pathways that play a key role during infection.

Glyceraldehyde -3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D - glyceraldehyde 3 - phosphate (G3P) into 3 - phospho - D - glyceroyl phosphate.

The SIGMA project aims to develop novel biomedical approaches to treat this devastating disease by applying powerful sequencing technologies to discover the genes and key pathways underlying common varieties of cancer.

p70S6K, a key element of mTOR pathway, promotes cell growth by inducing protein synthesis and cell survival by phosphorylating (inactivating) the proapoptotic protein BAD (31, 32).

Find available products by clicking on key proteins in the PI3K - AKT interactive pathway below.

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth - control pathway.

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

For example, the insulin receptor substrate and phosphotyrosine binding proteins GAB1 / GAB2 emerged on the metazoan stem after the divergence of choanoflagellates, indicating that an insulin - signalling - like pathway may have been a key regulator of growth in early animals by tying into the ancient PDK1 and Akt kinases (Fig. 2b).

Background: Small non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free - living and parasitic lineages of flatworms, but only few key factors of the small RNA pathways have been exhaustively investigated in a limited number of species.

By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the diseasBy targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the diseasby a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease.

By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.

By comparing key biochemical reactions in the cells of fasted and fed scid and B6 mice, the research team was able to identify and describe the highlighted steps (formerly missing links) in the following feeding - induced insulin signaling pathway.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

Mercury and other toxic metals further contribute to cancer development and growth by preventing the biosynthesis and functioning of vitalethine, an endogenous regulator of key metabolic pathways necessary for a «vital» immune system.

The aim is to reduce the widening skills gap by providing hands on experiences, allowing young people to explore skills and vocational pathways and motivating them to find out more about the world of work, industry brands and key organisations.

It is expected that 90 per cent of all future jobs will require digital skills and it is estimated that the UK will need more than 1.2 million new technical and digitally skilled people by 2022 to satisfy future skills needs, computer science GCSE is one of the key pathways that young people can take.

Therefore, it is important for educators working with traumatised children to understand the key developmental pathways that may be affected by childhood trauma, and how to support resilience through these pathways (Perkins, & Graham - Bermann, 2012).

By combining key features of both platforms, the new ePortal will help districts provide more and greater variety of WBL opportunities to their pathway students.

Provide support for teacher - designed leadership plans that address student learning within one key leadership pathway, followed by the demonstration of these plans» progress and results.

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