Sentences with phrase «key pathways in»

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Further, growing research also implicates mitochondrial dysfunction as a key pathway in the development of neurodegenerative diseases.

Not exact matches

The key is to know where you are in your pathway and what else lies in front of you.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

Knowing the key players in the entire NOD2 pathway, from initiators to enhancers, would pave the way for new strategies to treat inflammatory diseases, Mr Stafford said.

The elucidation of key steps in this biochemical pathway had won Calvin the 1961 Nobel Prize in chemistry; during his acceptance speech at the Nobel ceremony in December that year, Calvin previewed his paper on the entire pathway.

The key proteins at work in the nematodes have highly similar counterparts in humans, suggesting that similar regulatory pathways may operate in people.

A key breakthrough in the research came when the scientists discovered something that was previously unknown — a molecular mechanism in the Fanconi anemia DNA repair pathway apparently makes T - ALL resistant to chemotherapy.

Co-author Fred Reike, who specialises in retinal disease, says that quantum dots have great potential in this area because they directly affect ion channels, which play a key part in the signalling pathways of vision.

The idea is also to engineer the new organism, deleting key metabolic pathways, such that it would never survive in the wild in order to prevent escapes with unintended environmental impacts, among other dangers.

A particular enzyme in the pathway — phosphogluconate dehydrogenase (PGD)-- turned out to be key, enabling the conversion of glucose to metabolites that «can directly fuel tumor growth,» McDonald said.

By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last week.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

Mining that data is critical to developing therapies that target key points in relevant biological pathways — and represents opportunities for bioinformatics experts, Chung says.

She says mutations in key players of the mTOR pathway, a molecular pathway present and active in several types of cancer, have been identified in pNETs.

Kenneth Mann, a biochemist at the University of Vermont in Burlington, does not doubt that blocking these anticoagulant pathways will increase the production of thrombin, a key protein in clotting, but he does not think that these therapies will necessarily work for everyone.

Understanding what happens with the UPR in disease is key to illuminating the normal operation of this essential pathway — and to providing insights into the development of targeted therapies.

In addition, he touted the benefits of international research cooperation as a key pathway to innovation — a theme echoed by Moniz.

Researchers found long - lasting changes in key communication pathways in the brain.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

They found that the compound reduces levels of a key protein — known as IkappaBzeta — in the IL - 17 inflammatory pathway.

One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.

A fourth study finds that a generalized seizure leads to diminished short and long - term memory by interfering with key signaling pathways in the brain.

Their work implicated the Ras pathway — a calcium - dependent signaling network that spurs neuronal growth — as playing a key role in autism.

These findings suggest that the effects of prostaglandin on serotonin signaling are key drivers of the emotional response to pain, implicating a pathway that may be targeted in future therapeutics for managing pain in chronic inflammatory conditions.

The retrograde response pathway is specific to the yeast used in the study and supplies key amino acids to the cell by changing the metabolic process of the mitochondria.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorIn collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorin Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorin the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

Indeed, drugs that block a key repair pathway receptor exist and are undergoing testing in other diseases, Elias said.

The molecular structure of the two key lipid components in the newly discovered signaling pathway are ceramide (right) and cardiolipin (upper left).

Modeling and experiments show how a key transcription factor uses biochemical feedback in two separate pathways to trigger either sustained or transient inflammation.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

«Our work shows that L - arginine is a critical component in regulating a key pathway that promotes blood vessel development in the placenta.

«Using novel computational methods, we have pointed to new biological pathways that act in the brain to regulate overall obesity, and also to a different set of pathways related to fat distribution that regulate key metabolic processes,» says senior author Joel Hirschhorn, M.D., Ph.D., Concordia professor of pediatrics and professor of genetics at Boston Children's Hospital and Harvard Medical School, and co-director of the Broad Institute Metabolism Program.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

In their new paper, Cheyette and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorderIn their new paper, Cheyette and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorderin tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorderin schizophrenia, depression, bipolar disorder, and autism spectrum disorders.

The team demonstrated that GPR158 affects key signaling pathways involved in mood regulation in the region of the brain called prefrontal cortex, though the researchers emphasized that the exact mechanisms remain to be established.

Geschwind, a professor in the Russell H. Morgan Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center, and others at Johns Hopkins have been studying the experimental drug as a cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer cells.

By identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.»

The key insight that emerged is that the experience of danger follows two pathways in the brain: one conscious and rational, the other unconscious and innate.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

One of the most robust alterations was observed in the JAK - STAT3 pathway and the production of serum amyloid A (SAA)-- a protein which has only recently been identified as a key player in the body's immune response.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

«Once we can understand what the key pathways are that cause this variability, we can start to think about targeting those pathways, to combat alternate outcomes in cancer treatment, for example.»