Sentences with phrase «key proteins central»

Not exact matches

Additionally, the RBR protein HOIP forms the central unit of the linear ubiquitin chain — assembly complex (LUBAC), which has emerged as key regulator of the NF - κB pathway.

Scientists from the UNC School of Medicine have developed a new tool for studying a key process in cells called G - protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe disease, including cancers.

Hanna studies a protein known as Nr4a1, which responds to both inflammatory and stress signals and the researchers hypothesized that it may be a key factor in the prevention of autoimmunity affecting the central nervous system.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).