Sentences with phrase «key receptors on»

Not exact matches

Results of the new study build on previous findings by Hackam's team showing that a protein called TLR4 (toll - like receptor 4) is a key instigator of the intestinal damage seen in NEC.

The key actors here likely are mu - opioid receptors, molecules on cell membranes that allow opioids to bind to them and interact with the cell itself, he says.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

Lanza also designed the nanoparticles to carry targeting molecules that home in on and bind to cancer cells that carry the complementary receptor, like a lock and key.

The key discovery made by the CSHL team is that FER is able to activate a receptor on the surface of ovarian cells «from below,» as it were — by interacting with a portion of the receptor that penetrates the cell membrane and plunges into the cytoplasm.

In a paper published June 11 in the early - online edition of Neuron, researchers at the Buck Institute for Research on Aging and the University of California, Berkeley have identified a serotonin receptor, HTR7, as a key mediator of eczema and other forms of itch.

Cannabinoid receptors are part of a large class of receptors known as G protein - coupled receptors (GPCR), which account for about 40 percent of all prescription pharmaceuticals on the market, and play key roles in many physiological functions.

A search of the CRISP database of NIH - funded research projects on three key words — mutant, androgen, and receptor — yields 24 projects funded since 1999 by nine different NIH institutes: the National Cancer Institute (eight projects), the National Institute of General Medical Sciences (NIGMS, three projects), the National Institute of Child Health and Human Development (three projects), the National Institute of Diabetes and Digestive and Kidney Diseases (two projects), and the National Center for Research Resources (two projects).

Think of brain cells as rooms with locks called receptors on their surfaces and a hypocretin as a key that is also a stimulant.

When attractant or repellant chemicals attach themselves to receptor sites on the surface membrane of a bacterium, it triggers a process within the cell that leads to the modification of the signal protein, CheY (pronounced «Key - Y»), enabling it to bind to the switch and change the bacteria's direction of movement.

Key to the researchers» efforts to track oxytocin at work in individual brain cells was use of an antibody developed at NYU Langone that specifically binds to oxytocin - receptor proteins on each neuron, allowing the cells to be seen with a microscope.

The ccr5 receptor, a protein found on the surface of cd4 T - cell lymphocytes in the immune system (try saying that quickly), may hold the key to ending the aids pandemic (see «The End of AIDS»).

These signals generally work like a key (the peptide) fitting into a lock on the surface of a cell (the protein receptor).

«Unlocking the mystery on how plant leaves grow their teeth: Discovery of EPFL2 peptide (key) and its receptor (lock) that make zigzag edges on leaves.»

It has to contact a receptor, fitting into it as a key into a lock, to send the message on.

Adenosine helps to sustain such cells by fitting into a protein called the A2A adenosine receptor on their surfaces, like a key into a lock.

To cause an infection, viruses work like a lock and key, attaching to specific receptors on cells to take hold and spread.

«This supports other data that GABA receptors are key in the actions of alcohol and that targeting this interaction is a viable approach to reducing alcohol intake,» says David Nutt of Imperial College London, former head of the British government's advisory committee on drugs.

The gene Gas5Â acts as a brake on steroid hormone receptors, making it a key player in diseases such as hormone - sensitive prostate and breast cancer.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

The impact of common dopamine D2 receptor gene polymorphisms on D2 / 3 receptor availability: C957T as a key determinant in putamen and ventral striatum.

Synaptic functions will be investigated in physiological and pathological context, using patient's autoantibodies as research tools, by focusing on NMDA receptor and key partners, VEGFR2, EphB2, CRMP2 and CRMP5.

On the next slide I show you basically the key domain that's involved in this signaling interaction, so when the insulin receptor is phosphorylated, in order to recruit adaptors such as IRS - 1, it uses an important domain called the PTP domain, or phosphotyrosine containing peptides that can actually mediate this interaction, and lead to the interaction of these various molecules within the pathway.

For example, the insulin receptor substrate and phosphotyrosine binding proteins GAB1 / GAB2 emerged on the metazoan stem after the divergence of choanoflagellates, indicating that an insulin - signalling - like pathway may have been a key regulator of growth in early animals by tying into the ancient PDK1 and Akt kinases (Fig. 2b).

The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G - protein coupled receptors (GPCRs), ion channels, kinases and other key enzymes, membrane proteins (e.g., receptors), and secreted proteins.

The — the keyhole is receptor site, whether it's a GLUT4 key which is that's allowing sugar into the muscle or whether it's on the liver and an — various different GLUTs.

Cruciferous vegetables — broccoli, Brussels sprouts, kale, cauliflower, cabbage — contain a phytonutrient that is transformed by our stomach acid into the key that fits into the Ah receptor locks on our intraepithelial lymphocytes, leading to their activation.

This stimulation of the NMDA receptor is believed to have two key effects on sleep: inhibiting muscle activity during rapid eye movement (REM) sleep, and lowering core body temperature enough to facilitate sleep in the first place.

receptor sites: molecules on the surface of the body's cells that allow specific hormones to pass into the cell (via a lock - and - key effect) to perform their regulatory function.

Insulin works by binding with receptors on cells throughout the body much like a key fits into a lock.