Sentences with phrase «key roles genes»

While most of biology and medicine focus on the key roles genes and chemicals play in the formation and control of living systems, the spatial arrangement of the components that make up those systems and the physical forces they experience are being increasingly recognized as equally important.

Not exact matches

In other words, these four genes likely play a key role in the biology of the disorder.

Following this in 2015, an article (Alsaweed et al.) described over 300 novel milk microRNA molecules, components that are known to play a key role in the regulation of gene expression.

Together, these experiments show that the PERIOD3 gene likely plays a key role in regulating the sleep - wake cycle, influencing mood and regulating the relationship between depression and seasonal changes in light availability, the team reports today in the Proceedings of the National Academy of Sciences.

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

But a new study, published today in Nature, has revealed that m6A plays a key role in the regulation of the Sex - lethal (Sxl) gene, which controls sex determination of the fruit fly Drosophila.

The researchers conclude that the mutated gene likely plays a key role in predisposing people to allergy.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

In the past decade or so, researchers have also come to appreciate the key roles played by chromatin proteins and RNA in regulating gene expression.

Moreover, some researchers say, the observation that MCPH patients can speak, and that they suffer at most from moderate retardation, indicates that the ASPM gene is not key to intelligence itself — whether or not it might have played a role in scaling up the hominid brain to modern dimensions.

The fact that so many proteins interact with the 26 bait proteins indicates that these original proteins play key roles in a complex process that wasn't apparent on the level of the «suspect» genes.

The egg's very structure, its scaffolding of proteins that guide the chromosomes during cell division, may also play a key role in turning on the necessary genes.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

Mice with mutations in what is called the nude gene don't fully develop the thymus, a small organ in the chest cavity that plays a key role in the maturation of infection - fighting T cells.

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells grow.»

Comparing proteins produced by normal genes to those produced by mutant Bt resistant ones, the team discovered that enzymes play a key role in determining whether or not a worm succumbs to the toxin.

The researchers also found differences in microRNA expression in bipolar cells — tiny fragments of RNA that play key roles in the «reading» of genes.

She notes that a few of the genes the team identified code for glutamate receptors, which play a key role in learning and memory and may have been selected in humans as well.

The full readout of what genes are on and off in dermal papilla cells has never been collected before, so researchers now have a new list of thousands of genes to study further that may play key roles in hair follicle development.

The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.

«Mysterious» non-protein-coding RNAs play important roles in gene expression: Study describes how enhancer RNAs are key to gene expression, possibly cancer mutations.»

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

They found what they were looking for on the CNGA3 gene, which encodes a cyclic nucleotide channel and plays a key role in transducing visual signals.

To find the new mutation, the scientists looked at five key genes that play a role in phototransduction, or the process by which light signals are transmitted through the eye to the brain.

The team also recently obtained a grant from the National Medical Research Council in Singapore to pursue a study using the probe to examine the relationship between key Parkinson's disease - linked genes and MAO - B expression and activity to further understand the causes of the disease and illuminate the role of MAO - B in this.

The gene plays a key role in cellular proliferation and is activated in 90 % of all human pancreatic tumors.

Germany's Max Delbrück Center for Molecular Medicine (MDC) Berlin Buch and the Fu Wai Hospital of the Chinese Academy of Medical Sciences (CAMS) are building a new gene research laboratory in Beijing, the aim being to identify genes that play a key role in the pathogenesis of cardiovascular diseases.

Furthermore, removing genes that facilitate conjugation halted gene transfer altogether, suggesting that they play a key role in the process.

Rbfox1 proteins were known to play a key role in splicing together coding portions of genes called exons to form mRNA, which is subsequently translated to form proteins.

A University of Toronto (U of T) study on fruit flies has uncovered a gene that could play a key role in obesity in humans.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Both papers analyzed members of the RAF gene family that play key roles in driving cancer.

«Genes play key role in parenting: Children also shape parents» behavior.»

Methyl labels in the DNA play a key role in this «epigenetic» regulation of gene activity.

The HLA (human leukocyte antigen) is a system of genes responsible for regulating immune responses, and peptides are short chains of amino acids that play key roles in regulating the activities of other molecules.

Light played a key role in the experiment because it allowed the researchers to switch on genes that they had added to the yeast cells.

Single - stranded, noncoding micro-ribonucleic acids (microRNAs), consisting of 18 - 23 nucleotides, play a key role in regulating gene expression.

Taking advantage of these «simplified» versions of melanoma, the researchers identified a dozen of new genes that are likely to play key roles in the initiation and / or progression of human melanoma.

Academic scientists are stewing about a recently issued patent that gives a private company the rights to CCR5, a human gene that plays a key role in HIV infection.

MicroRNAs regulate gene expression and play key roles in many biological processes, such as cell death and metabolism.

Many of the insertion sites were located within genes that play key roles in normal brain function.

«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple, group interactions that could play a key role in the regulation of genes,» explains Nicodemi.

Wolf and his colleagues have used the CRISPR - Cas9 system in bovine embryos to delete OCT4, a gene that is known to play a key role in the regulation of pluripotency in mammalian embryos.

The transcriptomics and phosphoproteomics data generated by this project will allow the identification of novel host and parasite genes and pathways that play a key role during infection.

October 21, 1994 Immortalizing agent of tumor cells found in yeast Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal.

A variant in a region of the genome that is not coding for a protein can have a relatively large effect on a gene regulating bone health,» says Dr. Douglas Kiel, whose NIH - funded team at Hebrew SeniorLife and Harvard Medical School played a key role in the effort.

Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal, offering scientists a tantalizing target for new anticancer drugs of greater effectiveness and lower toxicity.

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

Marta received the award for her work on the gene ARHGAP11B present only in humans and its key role in the expansion of the neocortex and brain evolution.