Sentences with phrase «key transcription factors»

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

Austin Smith of the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute teamed up with investigators from the Microsoft Research Computational Science Laboratory, also in the U.K., to incorporate experimental data on 20 key transcription factors involved in stem cell self - renewal.

What are the direct targets of key transcription factors that regulate cardiogenesis and cardiomyocyte differentiation and how do they function in networks?

Modeling and experiments show how a key transcription factor uses biochemical feedback in two separate pathways to trigger either sustained or transient inflammation.

The study focused on a key transcription factor in Arabidopsis called «Short - root,» so named because plants with harmful versions of the Short - root gene have stunted roots.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

A key transcription factor involved in expression of pro-inflammatory cytokines and senescence is Nuclear factor - kB (NF - kB) 24.

ES cells can be described based on a characteristic morphology, the presence of cell surface markers such as SSEA - 1 and Pecam1, or the expression of the key transcription factors such as Oct4, Sox2, Nanog, and a number of ES cell - specific transcripts (ECATs)[4]--[6].

Likewise, the expression pattern of cdx - 2, a key transcription factor in the trophoblast lineage, overlaps with that of Oct - 4, but within any blastomere, cdx - 2 expression bears no consistent relationship to that of Oct - 4 or nanog until after the trophectoderm lineage has been sorted [9].