The study, led by Katalin Susztak, MD, PhD, a professor of Renal - Electrolyte and Hypertension and Genetics, also identified three novel cell populations, along with all previously described
kidney cell types.
«Massive single - cell survey of
kidney cell types reveals new paths to disease: Study of over 57,000 cells from mouse kidneys help identify human renal disorders.»
Not exact matches
The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic
kidney cells, brain
cell samples and neurons derived from the stem
cells of healthy people and those with spinal muscular atrophy
type I and II.
In their latest study, they tested compounds against
cells from nine different
types of human cancer, including common
types affecting blood, colon, breast, prostate, ovaries,
kidneys, and lungs.
«Virtual tissue technology reveals new drug target in polycystic
kidney disease: Advanced computer simulations show that failures of
cell adhesion and inhibition cause two
types of
kidney cyst formation.»
In previous studies, including recent genome sequencing of cancer patients, human SETD2 has been implicated in several cancer
types, especially in renal
cell carcinoma — the most common kind of
kidney cancer.
Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and
Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in
cell and rodent models of
type 1 and 2 diabetes, chemotherapy - induced neuropathy and HIV.
The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during
kidney development, as well as in the timing, scale, organization, and molecular profile of key
cell types and
cell structures.
Next, the researchers would like to investigate how to culture the other
types of progenitor
cells that are required for a full
kidney, in addition to the nephrons formed by NPCs.
Salk Institute scientists have discovered the holy grail of endless youthfulness — at least when it comes to one
type of human
kidney precursor
cell.
«Each
cell in the
kidney seems to have a unique non-redundant function, and dysfunction of specific
cell types present with specific symptoms in people.
The Penn team unexpectedly found that what they thought were two irreversibly differentiated and distinct
cell types in the
kidney could convert to each other.
Using mice bred to lack some
types of lymphoid
cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that lymphoid
cells were not the perpetrators of
kidney disease.
To create the repository, the researchers are taking blood
cells from Gulf War veterans and «reprogramming» them into their «pluripotent» state, which can then be transformed into any
type of
cell, from a
kidney to a neuron.
The team found evidence of the process in several other
cell types, including breast, ovarian, umbilical cord, and
kidney cancer
cells.
The answer was yes: They found
cells with markers from all three major body
cell types, called germ layers: ectoderm (such as nerve
cells), mesoderm (muscle and blood vessel
cells), and endoderm (
kidney cells).
A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal
cell carcinoma, a
type of
kidney cancer.
The study is published in the scientific journal Oncoimmunology and describes how a
cell type in the blood, the neutrophil, causes
kidney dysfunction in mice with cancer.
A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain
types of leukemia, lung cancer,
kidney cancer and squamous
cell cancer of the head and neck.
An alternative possibility is that successful propagation of TMAdV may depend on infection of a specific host
cell type, such as A549 lung, and not BSC - 1 or PMK
kidney cells.
The mesoderm, for example, gives rise to key
cell types, including cardiac and skeletal muscle, connective tissue, bone, blood vessels, blood
cells, cartilage and portions of the
kidneys and skin.
An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various
types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with
kidney cancer, and 18 percent of patients with advanced non-small
cell lung cancer.
$ 1.8 M Supports Cancer Drug Discovery on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric Stem
Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian Cancer GMNews.com - March 2, 2016 Differences in
Type of Small Protein may further Elucidate Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign
Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the Lung Cancer Ribbon?
One of these tissue
types, specifically the mesoderm, develops into skeletal muscle
cells (along with other
cell types, including cardiac muscle,
kidney cells, red blood
cells, and smooth muscle).
This part will enroll subjects with certain
types of endometrial cancer, melanoma, non-small
cell lung cancer, and renal (
kidney) cancer.
Myofibroblasts can proliferate elsewhere in the body as well — although they may arise from different
cell types in different tissues — and fibrotic remodeling of the
kidney, liver (cirrhosis of the liver) and lungs follows a similar progression, Genin says.
Petrelli A, Tresoldi E, Mfarrej BG, Paganelli A, Spotti D, Caldara R, Secchi A, Battaglia M. Generation of donor - specific T regulatory
type 1 (Tr1)
cells from patients on dialysis for
cell therapy after
kidney transplantation.
Human embryonic stem
cells can turn into a variety of different
cell types, including (A) gut, (B) neural
cells, (C) bone marrow
cells, (D) cartilage, (E) muscle, and (F)
kidney cells.
Human embryonic stem
cells grown at the University of Wisconsin - Madison randomly changed into
cell types found in the A) gut B) brain C) bone marrow D) cartilage E) muscle F)
kidney Scientists haven't learned to control the development.
Kidney cancer — also called renal
cell cancer — is one of the major
types of cancer for which new immune - based cancer treatments are currently in development.
Researchers at Whitehead Institute have identified a key target protein of glucocorticoids, the drugs that are used to increase red blood
cell production in patients with certain
types of anemia, including those resulting from trauma, sepsis, malaria,
kidney dialysis, and chemotherapy.
Sorbitol is a sugar which accumulates in
kidney cells, nerve
cells, and
cells in the eyes of
type 2 diabetes patients.
Talk to your veterinarian based on the
cell type, pre-surgery blood work (how is her
kidney function, how is her liver function, etc?)
If a cause isn't found, a renal biopsy can be taken for histopathology so that
types of
cells and structure of the
kidney can be analysed on a microscopic scale which may aid in the diagnosis; however, the renal biopsy isn't always reliable.
For every
cell type you have in your body — liver
cells, skin
cells, brain
cells, muscle
cells,
kidney cells, and on and on — that
type of cancer can develop.
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver,
kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band
cell —
type of white blood
cell Baso basophil —
type of white blood
cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (
kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating
cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood
cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (
kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil —
type of white blood
cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood
cells Hb, Hgb hemoglobin — iron rich protein bound to red blood
cells that carries oxygen (anemia, red
cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed -
cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (
kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte —
type of white blood
cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red
cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed -
cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte —
type of white blood
cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood
cell — immature red blood
cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed -
cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (
kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet —
cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood
cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood
cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil —
type of white blood
cell USG Urine specific gravity (urine concentration,
kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (
kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (
kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood
cell count (infection, inflammation, bone marrow suppression)
Certain
types of matches contain chlorates, which could potentially damage blood
cells and result in difficulty breathing — or even
kidney disease in severe cases.
Published articles address a broad range of subjects relating to the
kidney and urinary tract, and may involve human or animal models, individual
cell types, and isolated membrane systems.