Sentences with phrase «kidney cysts»
«Our findings both validate and prompt further use of this first - in - kind fly model of kidney cyst formation in order to pinpoint the molecular and cellular mechanisms at work,» says Gamberi.
sciencedaily.com
The lower blood pressure group had a 14 percent decrease in kidney cyst size compared to those in the standard blood pressure group.
«The HALT - PKD findings show that people with polycystic kidney disease do not need to take both of the drugs studied to slow their rate of kidney cyst growth and decline in kidney function.»
Through an interdisciplinary approach that included genetic analyses, molecular biology, micro-dissection and drug screening, they have begun deciphering the biochemical pathways through which kidney cysts form.
In both studies, adding the second drug did not change kidney function or rate of increase in kidney cyst size.
The HALT - PKD trial enrolled volunteers to test whether a combination of commonly used FDA - approved drugs, lisinopril and telmisartan, could shrink kidney cysts and therefore slow progression of ADPKD, a genetic disorder characterized by growth of fluid - filled cysts in the kidneys.
Scientists at Royal Holloway, University of London, have discovered that a natural product found in grapefruit can prevent kidney cysts from forming.
In 2013, Dr. Patel and fellow researchers reported in Proceedings of the National Academy of Sciences that this microRNA cluster indeed appeared to promote kidney cyst growth.
«I hope that our studies will help define the precise cellular and molecular defects underlying kidney cyst formation,» she adds.
«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»
So we tested this in mouse models and in human polycystic kidney tissues, and, in both cases, high levels of pIgR were expressed in kidney cysts.»
It reveals that errors in how cells stick together give rise to two forms of kidney cysts.
Naringenin, which is also present in other citrus fruits, has been found to successfully block the formation of kidney cysts, an effect that occurs in polycystic kidney disease, by regulating the PKD2 protein responsible for the condition.
One of the studies also showed that rigorous blood pressure treatment slowed growth of kidney cysts, a marker of ADPKD, but had little effect on kidney function compared to standard blood pressure treatment.
Naringenin, which is also present in other citrus fruits, has been found to successfully block the formation of kidney cysts.
The test drug slowed the growth of kidney cysts in two mouse models and in cell cultures of human kidney cysts, the study showed.
«This is the first treatment that targets a mechanism that directly contributes to the development and growth of the kidney cysts in autosomal dominant polycystic kidney disease,» says Vicente Torres, M.D., Ph.D., director of Mayo Clinic's Translational Polycystic Kidney Disease Center.
Although the very early beginnings of the kidney cysts that will bring on this disease are present at birth, it is rare for them to cause obvious signs before the youngster is 6 months old and much more likely to begin considerably later in life than that.