Sentences with phrase «kidney development»

These categories involve cellular processes that occur early in kidney development.

These cells, however, are lost before or soon after birth when kidney development is completed.

Our research interests lie in the understanding of the molecular mechanisms governing kidney development.

The 3 research projects, all led by Andrew McMahon, PhD (Keck School of Medicine of the University of Southern California), looked at distinct aspects of kidney development in mice and humans, as well as the different types of cells involved.

«Mouse and human kidney development compared: Findings may lead to advances in the study and treatment of kidney disease.»

The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.

In an article published online ahead of print on Feb. 19, 2015 in the Journal of Biological Chemistry (JBC), investigators at the Medical University of South Carolina (MUSC) and the Ralph H. Johnson VA Medical Center report findings from in vitro and in vivo studies that elucidate the mechanisms underlying the impaired ciliogenesis and abnormal kidney development characteristic of polycystic kidney disease (PKD).

The research team further tested these organoids — three - dimensional organ structures grown in the lab — and found that they could be used to model kidney development and susceptibility of the kidney tissue to therapeutic drug toxicity.

«Further studies of Lin28 will teach us important lessons about kidney development and point to potential new interventions for kidney disease.»

Using normal kidney development as a roadmap, the BWH investigators developed an efficient method to create kidney precursor cells that self assemble into structures which mimic complex structures of the kidney.

Studies in the mouse model further suggest that controlled expression of Lin28 can promote kidney development and therefore may hold clues to regeneration of damaged kidneys in adults.

Generating NPCs in the lab, scientists believe, will offer a new way to study kidney development and eventually treat kidney diseases.

A paper on the work, «Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development,» was published in the journal eLife this week.

Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.

«Our method not only uses soluble factors that guide kidney development in the embryo but, by growing and differentiating stem cells on extracellular matrix components that are also contained in the membrane separating the glomerular blood and urinary systems, we more closely mimic the natural environment in which podocytes are induced and mature,» said Musah.

The data bring an understanding of human kidney development to a new level,» said Dr. McMahon.

Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).

The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, the effects of toxic drugs, and be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury.

When examined under a microscope, the tumors resemble immature embryonic kidneys, leading doctors to conclude that Wilms tumors form when kidney development, normally complete by birth, persists into childhood.

Now that the pieces are being connected and the role of prostaglandin is established, Wingert will turn attention to gaining a deeper molecular and mechanistic understanding of how the molecule works in kidney development, especially the gene targets of the signaling.

Involvement of laminin binding integrins and laminin - 5 in branching morphogenesis of the ureteric bud during kidney development.

It may also impair the baby's kidney development, and reduce calcium, which we've mentioned is needed for the infant's growth.

Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity.

«We analyzed human kidney development, identifying features that distinguish our kidney from its well - studied mouse counterpart.

Three new research articles compare human kidney development with a well - studied mouse model of kidney development to identify shared and novel features.

Research Interests: Kidney disease; HIV - associated nephropathy; APOL1 biology; Podocyte biology and kidney development; Basement membranes and extracellular matrix biology; Eukaryotic gene regulation

Members of the Wnt gene family (for «wingless,» originally discovered in fruit flies) were viewed as logical targets since they have been shown to interact in a variety of developmental systems, including tracheal development in fruit flies; neural patterning in frogs; and brain, tooth and kidney development in other vertebrates.

While mouse has been successfully used to study multiple aspects of kidney development, the amphibian pronephros of Xenopus offers a valuable alternative to explore the underlying molecular and cellular mechanisms.

Research Interests: Kidney Development; Polycystic Kidney Disease; miRNA; Posttranslational Regulation; Pronephros; Xenopus

While it sounds kinda gross, this circular process is actually important for baby's lung and kidney development.

Renal Dysplasia: abnormal kidney development that can lead to early kidney failure.