Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of
kidney structures in zebrafish, a widely used model for human kidneys.
Not exact matches
By analysing the
structure of uromodulin, the researchers write
in the journal PNAS that they can better understand the mutations that cause these
kidney diseases.
But he eventually did get a measure of recognition: The Wolffian body, an embryonic
structure in animals that develops into the
kidney, is named after him.
«We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into
kidney structures that resemble those found
in a normal human
kidney.
Greg Fahy of the American Red Cross
in Bethesda, Maryland, said last week that he and his colleagues hope to have developed a method for preserving rabbit
kidneys — which are very similar
in tissue type and
structure to human ones — by Christmas.
In the mouse study, the insulin - producing cells were placed under the
kidney capsule — a thin membrane layer that surrounds the
kidney — where they developed into an organ - like
structure with its own blood supply.
Contrast agents, injected into the patient during an MRI procedure and designed to be quickly cleared from the body by the
kidneys afterwards, are needed to make fine details of organ
structures, blood vessels, and other specific tissues clearly visible
in the images.
The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences
in gene expression during
kidney development, as well as
in the timing, scale, organization, and molecular profile of key cell types and cell
structures.
The results, which appear
in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to new avenues for research into the processes that direct cells to form functional
kidney structures.
At the end of 2013, they reported the successful creation of an
in vitro three - dimensional
kidney structure from human iPS cells.
In addition, the findings may help guide emerging stem cell - directed technologies to generate normal
kidney structures for studying and treating human
kidney disease.
Resolvin D - 1 attenuated the signs of
kidney inflammation that were seen
in heart - attack mice not given the bioactive mediator — the non-resolvin D - 1 animals had distorted
kidney morphology, enhanced levels of the
kidney injury marker NGAL and diminished amounts of nephrin — a protein necessary for proper functioning of the
kidney —
in the podocytes of the
kidney filtering
structure.
In the Nature Communications study, UTSW researchers also reported how miR - 17 causes cyst proliferation: the molecule essentially reprograms the metabolism of
kidney cells so that cellular
structures called mitochondria use less nutrients, freeing up resources to instead make cell parts that become cysts.
With the loss of the cushioning effect provided by free - moving collagen
in the blood vessels, the force of the surge of blood that is driven into the arteries by the pumping action of the heart is carried directly to organs like the
kidneys and the brain, damaging to the
structures that filter our blood and that connect the functional regions of our brain, and putting us at risk of a stroke.
This lesson has been designed to act as an introduction to the anatomy of the
kidney before students move on to study each
structure of the nephron
in more detail.
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An ultrasound study will be valuable
in demonstrating how much normal
kidney structure remains.
Protein
in the urine can be caused by a variety of different conditions; if you are looking for non or minimal invasive procedures then ultrasound isn't invasive and can tell your Veterinarian a lot about the internal
structure of the
kidney's and any abnormalities, also a regular blood test (just taken with a needle from the fore leg) with biochemistry will give a good indication about protein levels
in the blood more importantly the albumin to globulin ratio as well as creatinine and urea which will help to determine Sebastian's internal health.
If a cause isn't found, a renal biopsy can be taken for histopathology so that types of cells and
structure of the
kidney can be analysed on a microscopic scale which may aid
in the diagnosis; however, the renal biopsy isn't always reliable.
An adrenal tumor removal is traditionally one of the most challenging procedures
in small animal surgery, as the adrenal gland is located
in a difficult position next the vena cava (the largest vein
in the abdomen) as well as the renal arteries and veins (to the
kidneys), the aorta, and other vital
structures.
In a normal animal, the cortices of the adrenal glands, small
structures located adjacent to the
kidneys, release hormones called glucocorticoids and mineralocorticoids.
When these
structures are damaged,
kidney function is greatly impaired and toxins build up
in the body, causing serious illness.
Glomerulonephritis, also known as glomerular nephritis (GN), is a specific type of renal (
kidney) disease characterized by inflammation of the glomeruli, which are the tiny
structures in the
kidneys that act as filters for the blood.
Cancers that move often become trapped
in the sieve - like
structures of the lungs, liver, bone marrow and
kidneys.
Closest to it is a narrow elongated platform held up by breast - like shapes and vaginal mounds, upon which rests a creature that appears to be all organs, veins and arteries, its
structure and coloration evocative of renderings of the human cardiovascular system with lungs, heart,
kidneys, and liver and its circulation of oxygen poor and rich blood identified
in red and blue.
Urology is a specialized area of medicine concerned with the health of the urinary bladder, genital
structures and
kidneys in men and women, as well as the testicles and prostate
in men.