Sentences with phrase «kidney tissue in»

release bacteria from their mouths into their bloodstream, resulting in inflammatory changes in the heart, liver, and kidney tissue in

It is interesting that we have an excess of kidney tissue in our body.

their mouths into their bloodstream, resulting in inflammatory changes in the heart, liver, and kidney tissue in

«First, by genetically modifying the iPS cells, we created human kidney tissue in vitro with green fluorescence.

Not exact matches

In selecting between two patients requiring a kidney transplant from one live donor, for example, the patient who exhibits the lower immunosuppressive reaction to the donor tissue might be judged the more suitable for the transplant.

Unfortunately, like most water - soluble vitamins, Vitamin B12 is stored in the liver, kidneys & other tissues & a deficiency may not show up for several years, which is a huge concern because after about 7 years of B12 deficiency there can be irreversible brain damage.

«If you grill a brain on the barbecue, you need to add fat from the kidneys, and you put the brain in lung tissue.»

I was one of those FTMs who experienced pain upon latching at a level 6 - 7 (and I've experienced 5 kidney stones so I have experience gauging pain) and was told it was simply «soreness» when in actuality it was tissue damage.

One person who donates organs (hearts, lungs, liver, kidneys, pancreas and intestines) can save up to eight lives, while a tissue or eye donor (corneas, bone, skin, heart valves, tendons, veins, etc.) can improve more tha 75 lives by restoring eyesight, helping fight infections in burn patients and preventing the loss of mobility and disability.

Stem cells in babies» urine seem to help regenerate kidney tissue, protecting it from toxic drugs and could pep up organs for transplantation

Such antibodies, when attached to DNA in complexes, get lodged in the walls of arteries and in tissues to cause inflammation that damages blood vessels, skin, joints and the kidneys as part of the most severe type of lupus, systemic lupus erythematosus (SLE).

Bones make hormones that chat with other organs and tissues, including the brain, kidneys and pancreas, experiments in mice have shown.

Moreover, use of the gel led to significantly lower levels of cisplatin in liver tissue 5 centimetres away from the cancer, and in the kidneys.

In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient's own cells.

Tissues outside of the bones don't naturally calcify, yet mineralization of organs, including the heart, blood vessels, and kidneys, occurs with age and is exacerbated in people with diabetes or kidney disease.

Because the NPTX2 gene is not expressed in normal kidney tissue, a drug designed to target its protein would provide a highly focused treatment, Dr. Copland says.

But it became increasingly difficult to maintain the balance of minerals and fluids in her body, and the generalized swelling of her tissues progressed as her kidneys began to fail.

We're hopeful that this finding will pave the way for the future creation of kidney tissues that could function in a patient and eliminate the need for transplantation from a donor.»

Lead author Christina von Roemeling, a graduate student at Mayo Clinic in Florida, used genomic profiling of nearly 100 kidney cancer patient samples to identify genes that were either over-expressed or under - expressed as compared to patient matched normal kidney tissue samples.

Lin28 is closely tied to organ and tissue development in organisms as diverse as worms and humans, and is active in the kidneys early in development.

Insert a section of that new kidney tissue, equal in weight to maybe 20 percent of the existing organ.

Greg Fahy of the American Red Cross in Bethesda, Maryland, said last week that he and his colleagues hope to have developed a method for preserving rabbit kidneys — which are very similar in tissue type and structure to human ones — by Christmas.

The researchers say their findings also shed new light on how kidney disease leads to an abnormal thickening of heart muscle tissue called hypertrophy, which is a leading cause of death in people with kidney disease caused by high blood pressure, diabetes, and other illnesses.

Because upper urinary tract cancer manifests itself in the kidneys, the researchers used the latest genetic sequencing methods to examine cancerous kidney tissue side by side with nearby nontumorous tissue.

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA - approved treatment that affects 200,000 people per year in the United States.

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

As fat cells bulge, the body tries to store glucose in other tissues, including the liver, kidney, heart, muscles, and blood vessels, where the rotting process takes hold.

«This is a unique platform to study interactions between drugs and cells or tissues, specifically in the kidney, where current models were lacking,» said Sakolish.

Ribeiro's team is now investigating the molecular composition of the fat around the kidneys, particularly tissue in close contact with tumours.

Currently, the only definitive way to distinguish rejection from other causes of kidney injury is by performing a biopsy, in which doctors remove a small piece of kidney tissue to look for rejection - associated damage.

Gorelick would also like to make sure that no dangerous levels of radiation are released as the bacteria die, noting that some buildup was seen in the kidney tissue of the mice treated in the new study.

A September 2002 follow - up study found no evidence for widespread transdifferentiation of blood - forming stem cells in brain, liver, kidney, gut and other tissues.

So we tested this in mouse models and in human polycystic kidney tissues, and, in both cases, high levels of pIgR were expressed in kidney cysts.»

Contrast agents, injected into the patient during an MRI procedure and designed to be quickly cleared from the body by the kidneys afterwards, are needed to make fine details of organ structures, blood vessels, and other specific tissues clearly visible in the images.

But given that the protein is found in so many tissues, it's puzzling that thalidomide has such specific effects on limbs, ears, eyes, gut, and kidneys.

Transplant recipients who receive a kidney, heart, or lung often develop an immune response to the foreign tissue in the form of antibodies referred as donor - specific HLA antibodies.

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.

However, it remained to be determined how similar the kidney tissue made in vitro was to that formed in a living body.

«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»

Furthermore, resolvin D - 1 reduced levels in kidney tissue of the proinflammatory cytokine mRNAs for Il - 6, Il -1-beta, Tnf - alpha and Tgf - beta, and it increased the levels for the reparative cytokines Mrc - 1 and Ym - 1.

This new approach offers a safer alternative to metal complexes, such as gadolinium that are commonly used to enhance MRI images but can have side effects in kidney patients and may build - up in the tissues of individuals needing multiple MRIs.

The disorder has an estimated prevalence of 1 in 70,000 births and can affect the liver, heart, kidneys, blood vessels and other tissues of the body.

Rare stem cells (in red) that give rise to scar - tissue secreting myofibroblast cells, here found near the blood vessels of a mouse kidney (in green).

We found that it significantly reduced inflammation in the fat tissues and improved kidney and liver disease.

The absolute wet weight of heart, spleen, and kidney tissues was significantly lower in IL - 15Rα — KO mice compared with B6129 mice.

These data demonstrate a preferential effect of loss of IL - 15Rα on normalized skeletal muscle mass that is not seen in non-skeletal muscle tissue (i.e., heart, spleen, kidney).

The researchers analyzed the concentrations of 5,713 different lipids, or fat molecules and their derivatives, present in samples of brain, kidney and muscle tissues taken from humans, chimpanzees, macaques and mice.

In addition to potential side effects, the number of renal biopsies a patient can undergo is limited because of damage to the kidney tissue.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.