Encapsulated toxin - producing stem cells (in blue) help
kill brain tumor cells in the tumor resection cavity (in green).
Not exact matches
His work indicates that this
cell surface marker could serve as a target for a novel
brain cancer vaccine or T -
cell therapies engineered to recognize and
kill tumors carrying that neoantigen.
In human
cells and in mice, the virus infected and
killed the stem
cells that become a glioblastoma, an aggressive
brain tumor, but left healthy
brain cells alone.
In the
Cell study, Dr. MassaguĂ©, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two
tumor types that often spread to the
brain — many cancer
cells that enter the
brain are
killed by astrocytes.
«Herpes - loaded stem
cells used to
kill brain tumors.»
An experimental drug in early development for aggressive
brain tumors can cross the blood -
brain tumor barrier,
kill tumor cells and block the growth of
tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
There is plenty of anecdotal evidence out there claiming a link between
cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the
brain cancer (malignant glioma) that
killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent
cell phone use, based on the fact that the
tumor developed on the side of the head against which he held his phone.
Subsequent surgery on vaccinated patients has shown that the T
cells are finding and
killing tumor cells in the
brain, but not enough of them.
«A few years ago we recognized that stem
cells could be used to continuously deliver these therapeutic toxins to
tumors in the
brain, but first we needed to genetically engineer stem
cells that could resist being
killed themselves by the toxins,» he said.
Because the stem
cells generate the
brain cancer
cells,
killing off the stem
cells might prevent
tumors from recurring.
Study author, Dr Timothy Humphrey said «Mutations in SETD2 are frequently found in kidney cancer and some childhood
brain tumors, so we were excited when we discovered that a new drug we were studying specifically
killed cancer
cells with this mutation.»
The screening revealed coibamide A to be capable of
killing many types of cancer
cells, but Ishmael decided to focus subsequent studies on two types in particular —
brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.
Researchers demonstrated that the drugs pemetrexed and gemcitabine
killed cells from mouse and human
brain tumors, called group 3 medulloblastoma, growing in the laboratory.
«Our results are the first to provide insight into ways of targeting multiple
brain metastatic deposits with stem -
cell - loaded oncolytic viruses that specifically
kill dividing
tumor cells.»
Investigators from Brigham and Women's Hospital (BWH) and the Harvard Stem
Cell Institute have a potential solution for how to
kill tumor cells that have metastasized to the
brain.
Treatment with HSV1 - TK is expected to
kill transduced
brain cells, thus exposing
tumor antigen.
The idea: trigger immune activity within the
brain itself to
kill remaining
tumor cells — the ones neurosurgeons can't take out, which make this type of
tumor so dangerous.