Sentences with phrase «kill cells infected»

These cells are highly specialized guardians of the immune system and their role is to kill cells infected by a virus, damaged cells, or cancer cells.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

Not exact matches

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

The virus does this because, unlike most microbes, Zika can pass from blood into the brain, where it infects and kills stem cells, having severe effects on developing brains.

HIV is a disease of the gut, a concept that's easy to lose sight of with all the attention paid to sexual transmission and blood measurements of the virus and the CD4 + T cells it infects and kills.

University of Melbourne Professor, Leann Tilley, an Australian Research Council Laureate Fellow at the Bio21 Institute, tested the new drug in red blood cells infected with parasites and found that it was as effective at killing the artemisinin resistant parasites as it was for the sensitive parasites.

An unknown component of breast milk appears to kill HIV particles and virus - infected cells, as well as blocking HIV transmission in mice with a human immune system.

The production of this protein in a nerve cell eventually kills it but it has long been thought that this protein can not spread out of the cell and infect and kill neighbouring ones.

In the presence of Acinetobacter and Akkermansia, they became a particular type of T helper cell, which trigger inflammation and help the immune system kill off invaders or infected cells, the researchers report today in the Proceedings of the National Academy of Sciences (PNAS).

While the individual effects of the drugs on virus - specific CTL differ somewhat depending on specific assays, schedules, and doses, treatment with any of the three HDAC inhibitors impaired the ability of CTL to kill HIV - infected immune cells.

Dr. Cripe and his colleagues at The Ohio State University, the University of Pittsburgh School of Medicine and Cincinnati Children's Hospital Medical Center tested how well the oncolytic viral therapy — a cancer - killing form of the herpes simplex virus, called oHSV — infected and killed tumor cells in mice with and without a healthy immune system.

This made it possible for their immune systems to produce sufficient amounts of CD8 T cells that were primed to attack and kill HIV - infected cells.

But infected cells can reach such high numbers that the progression to cancer is not terminated by the many mutations that kill the cells or make them nonfunctional.

People infected with HIV have few signs of microbial translocation during the first six months of infection as it takes time for the virus to kill off epithelial cells and weaken the gut wall so that bacteria can leak through — so treating them early could be more effective.

The researchers found that the protein, called VRC07 - αCD3, triggered the activation and killing of latently HIV - infected helper T cells when the cells were taken from patients on antiretroviral therapy and then incubated in the lab with the patients» own killer T cells.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

VRC07 - αCD3 facilitates the killing of latently HIV - infected cells in three steps.

He knew that HIV is a retrovirus — the subject of his own heralded research — and that retroviruses don't kill the host cells they infect.

Professor Dan Davis and his team at the Manchester Collaborative Centre for Inflammation Research, working in collaboration with global healthcare company GSK, investigated how different types of immune cells communicate with each other — and how they kill cancerous or infected cells.

Among the protagonists are B cells, which produce antibody molecules able to neutralize pathogens or mark them for destruction, and T cells, which prompt infected cells to kill themselves or secrete chemicals that direct the activities of other immune players.

Using an in vitro human blood brain barrier model, the researchers demonstrated that radiolabeled mAb2556 could cross the blood brain barrier and kill HIV - infected cells without any overt damage to the barrier itself.

Particularly prominent in the RNA - Seq analysis was the up - regulation of a number of granzymes, a group of proteinases secreted by immune cells that were originally thought to be involved in killing (via apoptosis) virus infected cells or other target cells.

One way to cure HIV - 1 would be to pharmacologically drive virus production in latently infected cells and then to get CD8 + T cells to kill these virus - spewing cells.

«Our study showed that RIT is able to kill HIV - infected cells both systemically and within the central nervous system.»

However, HAART can not kill the HIV - infected cells,» said the study's lead author, Ekaterina Dadachova, Ph.D., professor of radiology, microbiology and immunology at Albert Einstein College of Medicine in the Bronx, N.Y. «Any strategy for curing HIV infection must include a method to eliminate viral - infected cells.»

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

«When HAART and RIT are used together, they kill the virus and the infected cells, respectively.»

Most important, engineered CAR T - cells showed efficacy in attacking and killing HIV - infected cells.

When the CD4 on the CAR molecule binds to HIV, other regions of the CAR molecule signal the cell to become activated and kill the HIV infected cell.

Simultaneously, a cell - mediated immunity system also becomes active, deploying cytotoxic T - cells to directly recognize and kill pathogen - infected cells.

When stimulated outside the body, the CXCR5 - positive cells can attack and kill virus - infected Tfh cells.

Immune cells called T cells are also activated, in order to kill infected cells.

As the infection progresses, adaptive immune cells called T cells move to the area of infection, where they detect and kill infected cells.

Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.

Further searching turned up retroviral particles, which could kill white blood cells and which also reacted with antibodies from infected patients.

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

«While the results are certainly not what we hoped for, we have identified what might be an important barrier in killing HIV - infected cells,» said Jones.

Zika infects and kills Sertoli cells, the researchers found, and Sertoli cells don't regenerate.

Because the innate immune system wasn't killing off infected cells, the mice showed an increased viral load and delayed recovery.

The virus could actually help, since it would continue infecting and killing unchanged, vulnerable cells — decimating its own resources in the process.

Trigger - happy demolition crews patrol the area killing invaders and infected cells, then efficiently clean up the mess.

«ZBP1 does an amazing job of killing off infected cells.

Such drugs would modulate ZBP1's action — allowing the body to fight the virus by killing infected cells, but preventing that overreaction.

She found that the brain depends on a type of immune cell known as the T cell, which normally kills infected cells or leads other immune cells in a campaign against foreign invaders.

Several previous studies have explored whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.

These then make holes in the infected cell to inject toxic substances that kill both the cell and the pathogen.

In most cases, infected epithelial cells are quickly killed by CD8 + cells, a type of white blood cells; only occasionally does the infection overwhelm the immune system, resulting in a lesion.

Virologists have long known that HIV infects and kills CD4 + T cells, which mediate the body's immune response to viruses.

First, the viruses infect and kill cancer cells.