Not exact matches
In human
cells and in mice, the virus infected and
killed the stem
cells that become a
glioblastoma, an aggressive brain tumor, but left healthy brain
cells alone.
VIRUS VICTORY Zika virus (green) infects and
kills stem
cells (red) in human
glioblastoma tissue, without infecting healthy brain
cells.
«We showed that Zika virus can
kill the kind of
glioblastoma cells that tend to be resistant to current treatments and lead to death,» said Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine at Washington University School of Medicine and the study's co-senior author.
In collaboration with co-senior authors Diamond and Milan G. Chheda, MD, of Washington University School of Medicine, and Jeremy N. Rich, MD, of UC San Diego, Zhu tested whether the virus could
kill stem
cells in
glioblastomas removed from patients at diagnosis.
The screening revealed coibamide A to be capable of
killing many types of cancer
cells, but Ishmael decided to focus subsequent studies on two types in particular — brain tumors, or
glioblastomas, and a breast cancer subtype known as triple negative breast cancer.