The idea is to use the understanding of the pathways that adiponectin uses to
kill myeloma cells to create a drug that would do the same thing.
Not exact matches
Multiple
myeloma, he said, «had been a vague phrase» in his life until he himself was diagnosed with this blood cancer, which strikes just over 30,000 Americans each year and
kills about 12,600.
The researchers then tested the capacity of the modified cells to
kill human multiple
myeloma cells in laboratory studies and an animal model.
The investigational treatment was combined with chemotherapy and an autologous stem cell transplant — a new strategy designed to target and
kill the cells that give rise to
myeloma cells.
The researchers grew the modified cells in the lab to increase their numbers and then injected them into an animal model where they again
killed human
myeloma cells.
The researchers modified a type of human immune cell — called T lymphocytes, or T cells — to target a molecule called CS1, which is found on more than 95 percent of
myeloma cells, and to
kill the cells.
The new immune system that grows from the donor stem cells can recognize
myeloma cells as «foreign» and
kill them, which is known as the «graft - vs -
myeloma» effect.