Sentences with phrase «killer cell development»
My interest and expertise in immunotherapy started in early 1990s with animal models of IL - 2 and IL - 15 cytokines and natural killer cell development, continued with high dose IL - 2 studies and subsequently Phase I - III trials with both CTLA - 4 and PD1 / PDL -1 checkpoint inhibitors.
https://www.roswellpark.org/ Not exact matches
In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.
Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.
This biosynthetic hybrid stimulates the development of weak T regs into killer T cells that destroy the immune cells directing the autoimmune attack.
Natural killer cells serve important roles in clearing non-type 2 inflammatory cells, so identification of a defect in NK cell function in severe asthma provides a window for the development of new therapeutic approaches.
Another interesting finding was the impact of the antibody on CD4 + T cells, helper cells that promote the development of killer T cells called CD8 +, which target and destroy virus - infected liver cells.
One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.
Requirement for IRF - 1 in the microenvironment supporting development of natural killer cells.
«This is an exciting finding because it could possibly lead to the development of drugs that improve Natural Killer cell function,» said TSRI Associate Professor Karsten Sauer, who led the study.
They found that these killer T - cells are highly «cross-reactive», and respond to a variety of pathogen - derived antigens, which could lead to the breaking of self - tolerance and to the development of autoimmune disease, such as type 1 diabetes.
This finding sheds new light on how these killer T - cells are turned into rogues, leading to the development of type 1 diabetes.»
Ben - Eliyahu S, Page GG, Yirmiya R, et al: Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity.