Sentences with phrase «kinase akt»

Serine / threonine kinase AKT is a downstream kinase of PI3K and a critical PI3K effector [26].

Recent studies have established that nucleophosmin - ALK mediates oncogenesis, at least in part, through phosphorylation / activation of the serine / threonine kinase AKT (4, 5).

Not exact matches

In contrast, HPV - inactive tumors often have mutations in the PIK3CA / PTEN / AKT pathway, indicating that AKT kinase inhibitors may be effective treatment options for these patients.»

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akakt oncogene homologue (AktAkt).

Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal - regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.

The enhanced hiPS - HEP cells respond to insulin with phosphorylation of protein kinase B - α (Akt), even at low insulin concentrations, and the genes involved in glycogen metabolism, gluconeogenesis, and insulin signaling are expressed at similar levels as in hphep cells.

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt / PKB down - regulation and GSK3 activation.

Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3 - kinase / Akt / mTOR pathway and inhibition of autophagy.

Here, we show that enhanced hiPS - HEP cells respond to insulin with phosphorylation of protein kinase B - α (Akt), even at low insulin concentrations (Figure 4, Panels E and F), and that the genes involved in glycogen metabolism, gluconeogenesis, and insulin signaling are expressed at similar levels as in hphep cells (Figure 4, Panels B, C, and D).

Regulation of heme oxygenase - 1 expression by demethoxy curcuminoids through Nrf2 by a PI3 - kinase / Akt - mediated pathway in mouse β - cells.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

AKT is a downstream effector of phosphatidylinositol 3 - kinase (PI3K) and a critical mediator of mammalian target of rapamycin (mTOR) activity (6).

Additionally, ERK1 / 2 and AKT are known to cross talk with multiple substrates including several kinases, transcription factors, etc. which increase the complexity of the signaling network.

ERK1 / 2 activity was inhibited using U0126, PI3K - AKT kinase activity was inhibited using LY294002 and JNK activity was inhibited using SP600125 (all were from Calbiochem, USA).

[41] Approximately 50 % of cutaneous melanomas have an activating BRAF mutation, with an additional 10 % to 20 % having an activating mutation in NRAS; NRAS is an upstream partner of BRAF that also activates the phosphatidylinositol 3 - kinase (PI3K) / Akt / mammalian target of rapamycin (mTOR) pathway.

[42 - 46] KIT, a type III transmembrane receptor tyrosine kinase that sits upstream of NRAS and BRAF, feeds into several signaling pathways, including both the RAS / RAF / MEK / ERK cascade and the PI3K / Akt / mTOR pathway.

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors.

This is quite a complex pathway and I don't have time to go through details, but just briefly, glucose metabolism is regulated by insulin, so is lipid metabolism and this is one of many pathways where insulin activates a number of kinases, but particularly Akt.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

The present study analyzed the kinase pathway through which ActD induces p53, and found that AKT was phosphorylated and activated by ActD.

In addition, caffeine may increase the activity of several signaling enzymes, including the calcium - dependent protein kinase and protein kinase B (also called Akt), which have roles in muscle glucose uptake during and after exercise.

For example, the insulin receptor substrate and phosphotyrosine binding proteins GAB1 / GAB2 emerged on the metazoan stem after the divergence of choanoflagellates, indicating that an insulin - signalling - like pathway may have been a key regulator of growth in early animals by tying into the ancient PDK1 and Akt kinases (Fig. 2b).

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

Au - Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.: Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin - dependent kinase 2 and AKT inhibition.

[1] DIM was found to have «lung cancer preventive effects» mediated via modulation of the receptor tyrosine kinase / PI3K / Akt - signaling pathway.

Insulin - like growth factor - 1 (IGF - 1) inversely regulates atrophy - induced genes via the phosphatidylinositol 3 - kinase / Akt / mammalian target of rapamycin (PI3K / Akt / mTOR) pathway