Low levels of glutathione peroxidase 1 activity in selenium - deficient mouse liver affect c - Jun N -
terminal kinase activation and p53 phosphorylation on Ser - 15 in pro-oxidant-induced aponecrosis.
High humidity suppresses ssi4 - mediated cell death and disease resistance upstream of
MAP kinase activation, H2O2 production and defense gene expression
Cyanidin 3 - glucoside protects 3T3 - L1 adipocytes against H2O2 - or TNF - alpha - induced insulin resistance by inhibiting c - Jun NH2 - terminal
kinase activation.
As one of the possible mechanisms, AMP - activated protein
kinase activation would be associated with these changes, nevertheless, the AMP: ATP ratio was significantly decreased by administration of the anthocyanins.
Moreover, C3G treatment decreased c - Jun N - terminal
kinase activation and promoted phosphorylation and nuclear exclusion of forkhead box O1 after refeeding.